生物标志物 生物标志物
Desirée Conti1, Giulia Bechi Gabrielli2, Massimiliano Panigutti1
1Fondazione Santa Lucia IRCCS, Rome, Italy.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
神经成像揭示了前体性痴呆症与勒维体 (pro-DLB) 中显著的结构和功能性大脑变化. 像额叶和叶这样的区域的这些变化对于了解早期的亲DLB进展和诊断至关重要.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 痴呆症研究 痴呆症研究
背景情况:
- 带有勒维体的前体性痴呆症 (pro-DLB) 是一个最近定义的阶段.
- 亲-DLB的神经解剖学和功能相关物需要进一步澄清.
研究的目的:
- 系统地审查神经成像发现在亲DLB.
- 确定亲DLB的确定的神经解剖学和功能相关性.
主要方法:
- 在PubMed和Scopus进行了系统的文献搜索.
- 包括40项使用MRI,PET和SPECT检查亲DLB患者的研究.
- 评估结构 (灰质,白质) 和功能 (新陈代谢, perfusion,连接性) 数据.
主要成果:
- 额叶区域显示功能下降,缩和白质损伤.
- 帕里埃托-头部区域表现出低代谢,低 perfusion 和局部缩.
- 皮下变化包括Meynert缩的基底核和减少多巴胺转运器吸收.
结论:
- 结构性和功能性脑损伤在亲DLB中很明显,与临床表现一致.
- 额头和腰背脊的变化与注意力,执行力和视觉感知缺陷相关.
- 观察到胆和多巴胺系统的显著退化,突出显示神经成像生物标志物的实用性.
相关概念视频
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These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
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