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Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
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基础科学和病原发生学

Skarleth Cardenas Romero1, Mei-Yu Lai2, Matthew J Rosene3

  • 1BIDMC/Harvard Medical School, Boston, MA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
PubMed
概括

在阿尔茨海默氏病 (AD) 模型中,通过模仿减少的粉样蛋白β (Aβ) 生成的帕尔米托伊尔蛋白 thioesterase-1 (PPT1) 增强 lysosomal depalmitoylation. 这种方法有望通过恢复 lysosomal 功能来延缓 AD 病理.

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