生物标志物 生物标志物
Gaurav V Bhalerao1, Pawel J Markiewicz2, David L Thomas3
1Department of Psychiatry, Oxford Centre for Human Brain Activity (OHBA), Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, Oxfordshire, United Kingdom.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
在不同扫描仪之间协调脑MRI扫描对于多地点研究至关重要. 康巴特方法有效地减少了变异性,同时保留了生物信号,超过了其他测试过的协调技术.
科学领域:
- 神经成像是一种神经成像.
- 医学成像分析 医学成像分析
- 生物标志物开发 生物标志物开发
背景情况:
- 该DPUK PET-MR协调研究解决了来自多个PET-MR扫描仪的大脑扫描的变化.
- 优化临床试验设计和评估PET-MR方法是关键目标.
- 这项研究侧重于健康老年参与者的T1加权MRI扫描中的成像衍生表型 (IDP).
研究的目的:
- 从不同的PET-MR扫描仪获得的大脑扫描中量化内部和跨站点的变异性.
- 评估T1加权MRI扫描的各种协调方法的有效性.
- 提高早期痴呆症诊断的成像生物标志物的一致性.
主要方法:
- 使用英国生物银行 (UKB) 管道处理T1加权 (T1w) 扫描以提取体积内DPs.
- 评估了三种协调方法:基于图像质量指标 (IQM) 的回归,基于IDP的ComBat调整和基于图像的直方图匹配或SynthSR.
- 使用变化系数 (CoV) 量化了主体内部的变化;跨主体的变化也被评估.
主要成果:
- 视觉检查显示,扫描质量显著影响了受试者内部的变化.
- 纵向的ComBat有效地降低了Cov (例如,大脑体积:3.7±1.2%至1.4±0.8%),同时保持了跨主体的可变性.
- IQM回归降低了可变性,但也降低了跨主体的可变性;基于图像的方法显示了不一致或不兼容的结果.
结论:
- 在减少IDP变异方面,ComBat已经证明了其有效性,但需要特定的批量/地点变量定义.
- IQM回归提供了灵活性,但需要改进以保持跨主题的变化.
- 基于图像的协调方法需要进一步开发;对多地点MRI研究来说,量化各种变化方面至关重要.
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