Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Variable Aβ tracer uptake in hyperostosis frontalis interna: implications for brain Aβ PET/CT interpretation.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same author

Neuropathological study of the effects of aducanumab anti-Aβ immunotherapy on patients with Alzheimer's disease.

Acta neuropathologica·2026
Same author

Lipidated ApoE is found in nanoscale proximity to Aβ aggregates in human Alzheimer brains.

bioRxiv : the preprint server for biology·2026
Same author

Alzheimer's disease.

Lancet (London, England)·2026
Same author

Glial multicellular programs reveal distinct patient stratification in Parkinson's disease.

Research square·2026
Same author

Real-world comparison of brain [<sup>18</sup>F]FDG-PET imaging with CSF Alzheimer's disease biomarkers in a tertiary memory clinic setting.

EClinicalMedicine·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Correlates and predictors of self-efficacy among dementia caregivers: D-CARE findings.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

What should convince a clinician of disease modification in Alzheimer's disease clinical trials?

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Primary cilia-extracellular vesicle crosstalk in Alzheimer's disease: Emerging mechanisms and biomarker potential.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
查看所有相关文章

相关实验视频

Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

基础科学和病原发生学

Huan Li1,2, Theodore J Zwang1,2, Alberto Serrano-Pozo1,2

  • 1Massachusetts General Hospital, Boston, MA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
PubMed
概括
此摘要是机器生成的。

阿尔茨海默氏症 (AD) 涉及二/三层 (L2/3) 神经元的损失. 这项研究揭示了关键的微质和天体细胞相互作用与AD中L2/3神经元损失相关,突出了神经退行症中复杂的细胞通信.

更多相关视频

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

相关实验视频

Last Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

科学领域:

  • 神经科学是一个神经科学.
  • 基因组学就是基因组学.
  • 细胞生物学 细胞生物学

背景情况:

  • 阿尔茨海默病 (AD) 具有显著的新皮层2/3 (L2/3) 神经元损失的特征,与pTau和神经纤维结相关.
  • 虽然单核研究在L2/3神经元中探索了p-Tau机制,但非神经元细胞的作用在很大程度上仍然未知.
  • 这项研究通过使用单核RNA-Seq (snRNA-Seq) 和空间转录组学数据分析细胞-细胞通信来解决这个差距.

研究的目的:

  • 在阿尔茨海默病中研究L2/3神经元和非神经元细胞 (微质和星球细胞) 之间的细胞相互作用.
  • 确定涉及L2/3神经元损失的特定连接体受体对,以及它们与AD神经病理学的相关性.
  • 整合snRNA-Seq和空间转录组学,以了解非神经元细胞对AD病变的贡献.

主要方法:

  • 使用LIANA对来自AD连续体的32名捐赠者的snRNA-Seq数据进行了细胞与细胞相互作用分析.
  • 专注于L2/3神经元,星细胞和小质细胞在下回 (ITG) 之间的相互作用.
  • 利用空间转录组学进行初步分析AD捐赠者的L2/3神经元的相互作用特异性.

主要成果:

  • L2/3神经元与微质子集群mic.1 (抗原呈现,补充) 和mic.7 (细胞因子反应) 显著相互作用.
  • 在mic.1中的APOE表达与pTau正相关,与L2/3神经元比例负相关;在L2/3神经元中的LRP1显示了类似的相关性.
  • 星细胞和L2/3神经元之间的SEMA3D-PLXND1信号与pTau和L2/3神经元损失相关,尽管SEMA3D不是特定于层.

结论:

  • 综合性分析揭示了关键的连接体受体与微质细胞和星球细胞的相互作用,与AD中L2/3神经元损失相关.
  • 这些发现凸显了APOE和SEMA3D-PLXND1通路在AD相关神经退行症中的重要作用.
  • 强调神经元和非神经元细胞在阿尔茨海默氏病的发病过程中的复杂相互作用.