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相关概念视频

Infection01:20

Infection

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
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Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

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The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
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Cystic Fibrosis: Pathogenesis01:23

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Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
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Stages of Infection01:26

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Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
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Defense Against Bacterial Pathogens01:31

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The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
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Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
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基础科学和病原发生学

Wanyong Shin1, James B Leverenz1,2, Mark J Lowe1

  • 1Cleveland Clinic, Cleveland, OH, USA.

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|December 24, 2025
PubMed
概括
此摘要是机器生成的。

阿尔茨海默病 (AD) 与特定大脑区域的血脑屏障 (BBB) 透性增加有关,与认知能力下降的严重程度相关. 这些BBB变化在AD痴呆症中比轻度认知障碍 (MCI) 更明显.

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Last Updated: Jan 7, 2026

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科学领域:

  • 神经成像是一种神经成像.
  • 神经科学是一个神经科学.
  • 生物标志物 生物标志物

背景情况:

  • 阿尔茨海默病 (AD) 病理生理学涉及炎症和神经血管功能障碍.
  • 了解血脑屏障 (BBB) 的破坏对于AD研究至关重要.
  • 在AD的不同临床阶段,特定于大脑区域的BBB变化需要进一步的表征.

研究的目的:

  • 为了研究大脑区域特定的BBB透性在AD的不同临床阶段的变化.
  • 为了比较AD痴呆症,轻度认知障碍 (MCI) 和健康对照 (HC) 中的BBB透性.

主要方法:

  • 在3T时使用动态对比增强 (DCE) MRI 来评估BBB透性 (Ktrans).
  • 41名参与者 (6人患有AD痴呆症,16人患有MCI,19人患有HC) 使用帕特拉克模型进行了分析.
  • 在皮下灰质和叶状区域计算Ktrans值.

主要成果:

  • 与HC患者相比,在阿尔茨海默氏症患者的质体,尾状体,质体,杏仁体,海马体和部区域观察到显著更高的Ktrans值 (表明BBB透性增加).
  • 在Ktrans值和蒙特利尔认知评估 (MOCA) 分数之间发现了显著的负相关性,这表明BBB透性和认知功能之间存在联系.

结论:

  • 在特定的皮质下和皮质灰质区域增加的BBB透性在AD痴呆症中比MCI更为突出.
  • 这些BBB变化在AD患者和HC患者之间显著不同.
  • BBB中断的程度线性地跟踪了AD认知衰退的严重程度.