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相关概念视频

Infection01:20

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
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基础科学和病原发生学

Julia B Libby1, Philip L De Jager2,3, Vilas Menon3

  • 1Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.

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此摘要是机器生成的。

这项研究在阿尔茨海默病 (AD) 大脑中发现了许多翻译后修改 (PTM),揭示了蛋白质变化,粉样质斑块,团和认知衰退之间的新联系. 这些发现为AD提供了新的治疗点.

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科学领域:

  • 神经科学是一个神经科学.
  • 生物化学 生物化学
  • 蛋白质组学是指蛋白质组学.

背景情况:

  • 翻译后修改 (PTMs) 显著影响蛋白质功能,并与阿尔茨海默氏症 (AD) 病原发生有关.
  • 虽然像APP和MAPT这样的关键蛋白质中的PTM是已知的AD神经病理学的贡献者,但对AD大脑中全蛋白质的PTM缺乏全面的理解.

研究的目的:

  • 进行全蛋白质组调查,以确定AD大脑中与神经病理和认知衰退相关的PTM.
  • 发现新的PTM及其与AD特征的关联,包括粉样斑块和团.

主要方法:

  • 量谱法被用来量化超过51,000个PTMs在前额叶皮层的近10,000个蛋白质中,这些蛋白质来自不同认知状态 (认知正常,MCI,AD痴呆症) 的个人.
  • 分析的PTM包括乙化,无化,酸化和氨酸氧化.
  • 包括FDR校正在内的统计分析被用来将PTM与神经病理学指标 (tau纠密度,β-粉样蛋白负载) 和认知表现相关联.

主要成果:

  • 在MAPT中,已知的几个PTM位点与团密度有显著的关联.
  • 乙化APP-K687,一个与自身主导AD相关的部位,与增加的粉样蛋白负担相关.
  • 在特定的PTM (例如,无处不在,囊氧化) 和粉样蛋白负担,团密度和认知表现之间发现了新的关联.

结论:

  • 这项全蛋白质组研究突出显示了关键AD相关蛋白质 (MAPT,APP) 中既定和新型的PTM,并确定了与AD病理和认知障碍相关的新PTM.
  • 这些发现强调了AD大脑中显著的蛋白质基因变化,并提出了治疗干预的众多潜在目标.