生物标志物 生物标志物
Jr-Jiun Liou1, Tales Santini1, Jinghang Li1
1University of Pittsburgh, Pittsburgh, PA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
住院治疗COVID-19与持久的大脑健康影响有关,包括康复患者的认知功能下降和海马体积较小. 这些神经系统的变化凸显了严重疾病对大脑的严重影响.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 传染性疾病 传染性疾病
背景情况:
- 据怀疑COVID-19会影响大脑健康,临床MRI显示了各种神经症状.
- 这项研究调查了基于住院状态的康复COVID-19患者的神经成像,认知和血生物标志物.
研究的目的:
- 在住院和非住院COVID-19幸存者之间比较神经影像生物标志物,认知功能和血生物标志物.
- 为了确定严重的COVID-19疾病的持久神经影响.
主要方法:
- 179名参与者接受了7TMRI,认知测试 (MoCA,记忆,精神运动速度) 和血液采集.
- 神经成像包括形态测量,白质高强度 (WMH) 分段和海马体子场分析.
- 统计分析比较了使用t测试和ANCOVA的住院 (n=52) 和非住院 (n=111) 组.
主要成果:
- 住院患者的海马体积较小 (总体,右CA1) 和认知分数较低 (MoCA,Trail Making Test B,记忆,视觉空间构造).
- 在住院和非住院组中,WMH负担与认知得分有不同的关联.
- 海马体积与认知得分的关联在两组之间也存在显著差异,没有检测到血生物标志物差异.
结论:
- 住院治疗COVID-19与较差的认知表现和减少海马体积有关.
- 在住院患者中观察到大脑成像标记物和认知功能之间的明显关系.
- 这些发现强调了严重的COVID-19疾病持续的神经效应.
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516