生物标志物 生物标志物
Justin Jit Hong Ong1, Yi Jin Leow1,2, Jia Dong James Wang3
1Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
周血管空间 (PVS) 与阿尔茨海默病 (AD) 病理学和认知衰退有关. 较高的PVS负担与AD生物标志物和较差的认知功能相关,这表明PVS是早期检测标志物.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 生物标志物 生物标志物
背景情况:
- 周血管空间 (PVS) 是脑小血管疾病 (CSVD) 的关键标志物,也是血管对阿尔茨海默病 (AD) 的潜在指标.
- 虽然PVS与脑血管功能障碍有关,但它们在AD病理和认知衰退中的特定作用,特别是在多样化的人口中,需要进一步调查.
- 这项研究研究了PVS负担,AD血生物标志物和东南亚队列认知障碍之间的关系.
研究的目的:
- 评估基底质中的PVS负担与AD血生物标志物 (p-tau181,NfL,GFAP,Aβ42/40) 之间的关联.
- 评估多民族人口中PVS负担和认知功能之间的关系.
- 探索PVS作为早期痴呆症检测生物标志物的潜力.
主要方法:
- 从BIOCIS队列中对979名新加坡参与者 (平均年龄58.2岁) 进行了横截面研究.
- 神经心理学评估将参与者分为认知正常,主观认知衰退和轻度认知障碍组.
- 用MRI评估PVS和其他CSVD标志物;量化血AD生物标志物;根据相关共变量调整统计分析.
主要成果:
- 较高的PVS负担与高的GFAP,NfL和p-tau181强烈相关,与Aβ42/40比率相反.
- 与其他CSVD标志物相比,PVS在轻度认知障碍参与者中显示出与粉样β病理的最强相关性.
- 增加的PVS负担与较差的视觉空间和执行功能有关.
结论:
- 在临床前和前期的AD中,PVS负担作为脑血管功能障碍和粉样蛋白-tau病理的标志物.
- 作为一种可访问的MRI标记物,PVS可以增强AD的诊断框架.
- 将PVS评估纳入诊断方案可能有助于更早,更准确地识别患AD风险的个体.
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