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相关概念视频

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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生物标志物 生物标志物

Jennifer A Frontera1, Allal Boutajangout1,2,3, Joshua Chodosh1,2

  • 1NYU Grossman School of Medicine, New York, NY, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
PubMed
概括

后COVID-19认知障碍,或大脑雾,可能源于免疫疲劳和增加血脑屏障的透性. 这项研究发现,在SARS-CoV-2感染后经历脑雾的患者中,细胞因子水平较低,BBB破坏标志物较高.

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科学领域:

  • 神经科学是一个神经科学.
  • 免疫学 免疫学 免疫学
  • 传染性疾病 传染性疾病

背景情况:

  • 后COVID-19认知障碍的机制仍然不清楚.
  • 增加的血脑屏障 (BBB) 透性和免疫变化是可疑的贡献者.
  • 脑雾的特点是记忆力丧失和注意力集中困难,影响了许多SARS-CoV-2后患者.

研究的目的:

  • 为了研究后COVID-19脑雾背后潜在的生物学机制.
  • 为了比较脑雾患者和没有脑雾患者的炎症,BBB干扰和tau病理的血生物标志物.
  • 为了确定COVID-19患者与没有认知障碍之间的生物标志物的差异.

主要方法:

  • 横截面研究比较COVID-19阳性 (COV+) 和阴性 (COV-) 患者.
  • 定义的大脑雾是SARS-CoV-2感染后 (>1个月) 持续的认知症状.
  • 使用Simoa技术测量了血细胞因子,BBB标记物 (例如,肝素结合性表皮生长因子) 和化 (pTau).
  • 通过神经精神病学测试和医生共识诊断 (NACC标准) 评估认知功能.

主要成果:

  • 在脑雾患者中观察到几个细胞因子 (TNF-a,IL-4,IL-10,IL-22) 的较低水平.
  • 在脑雾患者中发现了BBB透性的标记物 (肝素结合性表皮生长因子,血管内皮生长因子,胎盘生长因子) 的增加.
  • 与认知正常个体相比,轻度认知障碍 (MCI) 的COVID-19患者表现出较低的TNF-a和较高的pTau-217 (在阿尔茨海默氏症病例中).

结论:

  • 研究结果表明,免疫力疲和BBB透性增加是COVID-19后脑雾的潜在机制.
  • 改变的病理标志物表明处理中断也可能导致认知缺陷.
  • 生物标志物分析提供了对SARS-CoV-2感染后神经系统后续病理生理学的见解.