生物标志物 生物标志物
Jennifer A Frontera1, Allal Boutajangout1,2,3, Joshua Chodosh1,2
1NYU Grossman School of Medicine, New York, NY, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
后COVID-19认知障碍,或大脑雾,可能源于免疫疲劳和增加血脑屏障的透性. 这项研究发现,在SARS-CoV-2感染后经历脑雾的患者中,细胞因子水平较低,BBB破坏标志物较高.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 后COVID-19认知障碍的机制仍然不清楚.
- 增加的血脑屏障 (BBB) 透性和免疫变化是可疑的贡献者.
- 脑雾的特点是记忆力丧失和注意力集中困难,影响了许多SARS-CoV-2后患者.
研究的目的:
- 为了研究后COVID-19脑雾背后潜在的生物学机制.
- 为了比较脑雾患者和没有脑雾患者的炎症,BBB干扰和tau病理的血生物标志物.
- 为了确定COVID-19患者与没有认知障碍之间的生物标志物的差异.
主要方法:
- 横截面研究比较COVID-19阳性 (COV+) 和阴性 (COV-) 患者.
- 定义的大脑雾是SARS-CoV-2感染后 (>1个月) 持续的认知症状.
- 使用Simoa技术测量了血细胞因子,BBB标记物 (例如,肝素结合性表皮生长因子) 和化 (pTau).
- 通过神经精神病学测试和医生共识诊断 (NACC标准) 评估认知功能.
主要成果:
- 在脑雾患者中观察到几个细胞因子 (TNF-a,IL-4,IL-10,IL-22) 的较低水平.
- 在脑雾患者中发现了BBB透性的标记物 (肝素结合性表皮生长因子,血管内皮生长因子,胎盘生长因子) 的增加.
- 与认知正常个体相比,轻度认知障碍 (MCI) 的COVID-19患者表现出较低的TNF-a和较高的pTau-217 (在阿尔茨海默氏症病例中).
结论:
- 研究结果表明,免疫力疲和BBB透性增加是COVID-19后脑雾的潜在机制.
- 改变的病理标志物表明处理中断也可能导致认知缺陷.
- 生物标志物分析提供了对SARS-CoV-2感染后神经系统后续病理生理学的见解.
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