生物标志物 生物标志物
Kavita Singh1, Kurt Schilling2, Yang An3
1Multiscale Imaging and Integrative Biophysics Unit, National Institute on Aging, NIH, Baltimore, MD, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
老年人的认知和运动障碍与大脑的重大变化有关. 综合赤字显示出更明显的灰色和白质变化,表明潜在的神经退行性疾病标志物.
科学领域:
- 神经成像是一种神经成像.
- 衰老研究研究 衰老研究
- 神经退行性疾病 神经退行性疾病
背景情况:
- 记忆丧失影响到超过65岁的40%的人,通常与早期的运动衰退有关,信号潜在的神经退行性疾病,如阿尔茨海默氏症.
- 时代元和运动区域的灰质 (GM) 和白质 (WM) 变化是衰老和阿尔茨海默病 (AD) 的关键指标.
研究的目的:
- 在老年人群中描述认知和运动障碍.
- 使用先进的MRI技术 (MAP-MRI和DTI) 评估GM和WM的微结构变化.
- 通过标准认知查 (MoCA) 验证成像发现.
主要方法:
- 利用了来自人类结合体项目-衰老 (HCP-A) 的707名受试者 (36-90岁) 的数据集.
- 将参与者分为四组 (认知运动正常,认知障碍,运动障碍,认知运动障碍),使用基于NIH-Fluid和步行耐力测量的k-means集群.
- 在细分的GM和WM区域检查了5个MAP-MRI和4个DTI指标,采用调整为共变量 (性别,年龄,BMI,地点) 的线性回归.
主要成果:
- 与认知运动正常 (CMN) 组相比,认知运动障碍 (CMI) 组在运动和认知运动区域显示出明显更高的MAP-MRI指标 (RTOP,RTAP,RTPP) 和较低的DTI指标 (RD,TR).
- 在CMN和认知障碍 (CI) 群体之间,在特定的大脑区域 (形,形,低形) 观察到显著的反向结果.
- 在CMN和运动障碍 (MI) 组之间没有发现显著差异.
结论:
- 同时的运动和认知障碍与老龄化人口中更显著的灰色和白质微观结构变化有关.
- 这些发现强调了评估老年人的认知和运动功能的重要性,以检测神经退行早期迹象.
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516