Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Somatostatin receptor subtypes 1 and 4 regulate neprilysin, the major amyloid-β degrading enzyme in brain.

Journal of Alzheimer's disease : JAD·2025
Same author

Elevated 24-hydroxycholesterol levels counteract okadaic acid-induced tau hyperphosphorylation and neuronal morphology impairment.

Neurobiology of disease·2025
Same author

Endogenous geminivirus-like elements in the genus Rhododendron provide insights into the evolutionary origins of the begomovirus nuclear shuttle protein.

Plant molecular biology·2025
Same author

Improved application of the inverse emulsion method for generating flexible asymmetric liposomes for DNA plasmid delivery.

Journal of liposome research·2025
Same author

Impaired astrocytic synaptic function by peripheral cholesterol metabolite 27-hydroxycholesterol.

Frontiers in cellular neuroscience·2024
Same author

Different effects of CYP27A1 and CYP7B1 on cognitive function: Two mouse models in comparison.

The Journal of steroid biochemistry and molecular biology·2023

相关实验视频

Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

基础科学和病原发生学

Raúl Loera-Valencia1

  • 1ITESM, Chihuahua, CI, Mexico.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
PubMed
概括
此摘要是机器生成的。

27-胆固醇 (27-OHC) 损害神经元和天体细胞功能,破坏突触蛋白和谷氨酸清除. 这种氧化诱导的神经毒性有助于神经退行和兴奋毒性.

更多相关视频

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

相关实验视频

Last Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

科学领域:

  • 神经科学是一个神经科学.
  • 分子生物学分子生物学
  • 生物化学 生物化学

背景情况:

  • 氧化醇和27-胆固醇 (27-OHC) 一样,与神经退行性疾病有关.
  • 27-OHC 破坏神经元和天体细胞功能,影响突触蛋白 (SNAP25,PSD95),可塑性调节器 (REST/PTBP1) 和天体细胞介导的谷氨酸平衡 (RAGE,GLT-1,GLAST).
  • 27-OHC神经毒性的机制尚未完全理解.

研究的目的:

  • 为了研究27-胆固醇 (27-OHC) 神经毒性的分子机制.
  • 评估27-OHC对突触蛋白,神经元可塑性和星细胞谷氨酸酸摄取的影响.
  • 确定神经元和天体细胞功能障碍中27-OHC的关键分子标.

主要方法:

  • 主要皮层神经元和星球细胞被用不同度的27-OHC.治疗.
  • 西方斑块,qPCR和免疫细胞化学被用来分析蛋白质和基因表达.
  • 进行了功能性检测,包括成像和谷氨酸摄入量.

主要成果:

  • 27-OHC减少了神经元中的SNAP25和PSD95表达,损害了突触完整性.
  • 神经元可塑性受到增加的REST和减少的PTBP1表达的影响.
  • 星球细胞显示RAGE增加和GLT-1/GLAST减少,导致谷氨酸吸收受损和兴奋毒性.

结论:

  • 27-OHC对神经元和天体细胞功能都有有害影响.
  • 包括SNAP25,PSD95,REST/PTBP1,RAGE,GLT-1和GLAST在内的关键分子标受到27-OHC的失调.
  • 针对这些途径为神经退行性疾病提供了潜在的治疗策略,这些疾病包括胆固醇阻断和兴奋毒性.