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在生殖失败时使用塔克罗利斯治疗

Koji Nakagawa¹, Yuji Orita², Keiji Kuroda³

¹Center for Reproductive Medicine and Implantation Research, Sugiyama Clinic Shinjuku, Japan.

Journal of reproductive immunology

|December 24, 2025

概括

使用塔克罗利斯的免疫疗法显示出在体外受精 (IVF) 后治疗重复植入失败 (RIF) 的前景. 大约三分之一的RIF病例可能涉及免疫成分,这表明塔克罗利斯可以提高怀孕成功率.

科学领域:

生殖免疫学生殖免疫学
在体外受精 (IVF)
免疫治疗是一种免疫疗法.

背景情况:

重复植入失败 (RIF) 影响了试管婴儿的成功,其中很大一部分可能与免疫因素有关.
塔克罗利斯是一种氨酸抑制剂,已在RIF中作为免疫疗法进行了大约十年的研究.
之前的研究报告了临床怀孕率约64%与tacrolimus治疗RIF.

研究的目的:

在RIF患者中重新评估tacrolimus免疫疗法的疗效.
评估RIF病例中免疫媒介排斥标记的流行程度.
为了探索潜在的扩大用于产科并发症中tacrolimus的指示.

主要方法:

在接受TACROLIMUS治疗的RIF患者中,对临床妊娠率的回顾性分析.
评估Th1/Th2细胞比率以确定免疫媒介排斥.
对RIF和相关产科疾病中塔克罗利斯的现有文献的审查.

主要成果:

一个最近的队列证明了临床怀孕率为57.1%与tacrolimus治疗RIF.
大约35.9%的RIF病例表现出Th1/Th2细胞比率,表明免疫媒介排斥.
塔克罗利木斯还显示出在治疗复发性流产 (RPL) 和预防产科并发症方面的潜力.

结论:

塔克罗利斯免疫疗法仍然是RIF的可行选择,实现高怀孕率.
显著比例的RIF病例具有免疫基础,支持免疫调节治疗.
需要进一步的确认性试验来确定塔克罗利斯在RIF和其他产科疾病中的作用.

关键词:

怀孕的高血压障碍 (HDP) 是一种过早分娩 (PTB) 是什么意思监管T (Treg) 细胞的监管塔克罗利慕斯可以使用.Th1/Th2 细胞的比率.

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