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两岁以下儿童的IL-17_A和肺炎球菌携带之间的关系:来自越南随机对照试验的数据
Zheng Quan Toh1, Yi Ying Ma1, Beth Temple2
1Infection, Immunity and Global Health, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia; Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia.
幼儿肺炎球菌携带与高水平的17A (IL-17A) 和相关的细胞因子有关. 这些发现表明IL-17A在肺炎球菌携带中发挥了作用,但在这个年龄组中没有其清除.
科学领域:
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
- 微生物学 微生物学
背景情况:
- 肺炎球菌的携带先于侵入性肺炎球菌病 (IPD).
- 干白素-17A (IL-17A) 和IL-17A生成细胞与成人肺炎球菌载体清除有关.
- IL-17A在儿科肺炎球菌携带中的作用尚不清楚.
研究的目的:
- 调查IL-17A,相关细胞因子 (IL-22,IL-23,IFNγ) 和IL-17A产生细胞与两岁以下儿童肺炎球菌携带之间的关联.
- 探索这些免疫标记物与携带的肺炎球菌血清型数量之间的关系.
主要方法:
- 分析了143名未接种疫苗的18个月儿童的血液样本和从出生到24个月的鼻抽样.
- 使用多重珠子阵列或ELISA测量血细胞因子度 (IL-17A,IL-22,IL-23,IFNγ).
- 通过外围血液单核细胞的流动细胞计量对IL-17A/IFNγ产生细胞的量化.
主要成果:
- 18个月后,在肺炎球菌携带者和非携带者之间观察到较高的IL-17A,IL-22,IL-23和IFNγ血度.
- 携带两个或两个以上肺炎球菌血清型的儿童表现出显著更高的IL-17A,IL-22和IL-23水平.
- 携带者和非携带者之间没有发现IL-17A产生细胞的差异;这些细胞因子没有预测24个月的肺炎球菌清除.
结论:
- 在两岁以下的儿童中,肺炎球菌携带与血IL-17A,IL-22和IL-23度升高有关.
- 虽然与携带相关,但IL-17A和相关细胞因子似乎不会影响这个年龄组的肺炎球菌清除.
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