生物标志物 生物标志物
Wen Zhang1,2, Sheelakumari Raghavan1, Jianqiao Tian1,3
1Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
衰老的白质表现出增加的新陈代谢,而不是降低,因为认知功能下降. 这种非典型的白质签名可能表明对衰老和疾病的补偿反应,可能与认知性有关.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 老年学是一门学科.
背景情况:
- 与灰色物质相比,老化和痴呆症中的白质 (WM) 代谢研究不足.
- 以前的研究集中在衰老和痴呆期间灰色物质 (GM) 的代谢减少.
研究的目的:
- 调查与衰老和痴呆相关的WM代谢变化.
- 检查WM新陈代谢,阿尔茨海默病 (AD) 生物标志物和认知衰退之间的关系.
主要方法:
- 分析了3,169名参与者的数据 (MCSA和ADNI) 使用MRI,粉样蛋白-PET和FDG-PET.
- 采用voxel-wise回归来识别与认知相关的WM代谢变化.
- 利用结构方程模型和回归分析来探索WM代谢的驱动因素和预测效用.
主要成果:
- 在冠状体辐射中确定了一种非典型的WM签名 (AWM-Signature),其代谢增加与认知能力下降相关.
- AWM-Signature 超高新陈代谢与年龄增长,氨基粉症,血管疾病,神经炎症和减少WM神经元密度有关.
- AWM-Signature超代谢预测了更快的认知衰退,与GM和典型的WM发现形成鲜明对比.
结论:
- 在衰老和疾病期间观察到冠状辐射体中WM代谢的意想不到的增加.
- 这些代谢变化可能代表一种补偿反应,可能表明认知性.
- 需要进一步的研究,以了解这些WM代谢变化在维持认知功能的作用.
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