生物标志物 生物标志物
Matthew S Panizzon1,2,3, Eric L Granholm4, Kristine C Dell3
1Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
瞳孔光响应 (PLR) 的变化与中年后期轻度认知障碍 (MCI) 有关. 特定的PLR措施预测转换为大赦MCI,表明PLR.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 老年学是一门学科.
背景情况:
- 在阿尔茨海默病和相关痴呆症 (ADRD) 中,观察到瞳孔光响应 (PLR) 改变.
- 作为ADRD或一般认知衰退的生物标志物,PLR的预测价值仍然在很大程度上是未知的.
研究的目的:
- 调查PLR与中年后期轻度认知障碍 (MCI) 之间的横截面关联.
- 为了确定PLR是否预测在6年的随访期内转换为MCI.
主要方法:
- 利用来自越南时代老龄化双胞胎研究 (VETSA) 队列的数据 (N=1070).
- 使用杰克-邦迪标准评估MCI状态,并使用NeurOptics PLR-200瞳孔计对瞳孔的反应.
- 对包括年龄,种族,抗胆固醇药物使用和双胞胎集在内的共变量进行控制.
主要成果:
- 峰值收缩幅度的降低与MCI的更高可能性显著相关 (OR=1.76).
- 扩张速度与6年内转化为大脑遗忘性MCI显著相关 (OR=1.97).
结论:
- PLR测量与MCI相关,并预测转换为大赦MCI,表明作为非侵入性生物标志物的潜力.
- 研究结果表明,PLR可以在明显症状出现之前识别有认知衰退和ADRD风险的个体.
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