[结膜的单侧儿科型毛囊性淋巴瘤]
S Mehal1, M De Massary1, R Dubois1
1CHRU, Lille, France.
Journal francais d'ophtalmologie
|December 24, 2025
概括
儿科类型的毛囊性淋巴瘤很少影响儿童的结膜. 这一案例凸显了在诊断这种不常见的轨道副淋巴瘤方面,组织病理学和分子分析的重要性.
科学领域:
- 眼科医生 眼科 眼科
- 儿科瘤学 儿科瘤学
- 血液学 血液学 血液学
背景情况:
- 儿科型毛囊性淋巴瘤 (PTFL) 通常影响儿科患者头部和部的淋巴结.
- 眼部附部的干扰,特别是结膜,是PTFL在这个年龄组中异常罕见的表现.
研究的目的:
- 报告一个罕见的儿科类型的毛囊性淋巴瘤的病例,涉及一个11岁男孩的结膜.
- 强调这种罕见的疾病的诊断挑战和必要的调查.
主要方法:
- 一个11岁男孩的鱼色结膜质量的临床表现.
- 切除活检与组织病理学和免疫组织化学分析.
- 光在位杂交 (FISH) 用于IGH重组和下一代测序 (NGS) 用于B细胞克隆性和IgkA重组.
主要成果:
- 组织病理学和免疫组织化学表明毛囊性淋巴瘤.
- 鱼类证实了IGH重新安排.
- 包括NGS在内的分子研究证实了IgkA基因重组,确定了儿童类型结膜毛囊淋巴瘤的诊断.
结论:
- 结膜性儿科型毛囊性淋巴瘤是一种罕见的,经常被忽视的儿童轨道附带性淋巴瘤.
- 由于非特异性临床特征,对于鱼颜色的结膜病变,高度的怀疑指数至关重要.
- 多学科评估,包括组织病理学和分子分析,对于准确的诊断至关重要.
相关概念视频
Glaucoma: Overview
1.2K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.2K
Secondary Lymphoid Organs
8.7K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
8.7K
Primary Lymphoid Organs
14.5K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
14.5K


