生物标志物 生物标志物
Roberto Vicidomini1, Rifa Sanjida Punnota1, Paul Edison1,2
1Imperial College London, London, Greater London, United Kingdom.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
乳腺癌患者的化疗相关认知障碍 (Chemobrain) 与大脑特定区域的灰质体积减少有关. 这些变化可能会增加神经退行性疾病 (如阿尔茨海默氏症) 的风险.
科学领域:
- 神经科学是一个神经科学.
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 化疗虽然可以改善癌症的存活率,但却会产生影响生活质量的副作用.
- 化疗相关的认知障碍 (Chemobrain) 影响约33%的乳腺癌患者,长期结果可变.
- 调查Chemobrain的原因和表型对于早期检测和管理至关重要.
研究的目的:
- 为了研究乳腺癌患者与没有Chemobrain之间的神经解剖学和认知差异.
- 为了确定受化疗诱导的认知变化影响的特定大脑区域.
主要方法:
- 使用人工智能平台对270名乳腺癌患者进行神经认知预查.
- 对18名得分较差的患者和19名对照患者进行了面对面的神经认知评估和3特斯拉MRI扫描.
- 感兴趣的区域 (ROI) 和基于Voxel的MRI图像的VBM分析.
主要成果:
- 化学脑患者的灰质体积和表面积在包括左侧带带状峡和关节在内的区域显著降低.
- 在化疗患者中,VBM分析显示,周周结膜区域,带状回环,前,状/中间额叶的灰质减少.
- 化学脑患者表现出较差的语义/口头流性和较低的MMSE分数.
结论:
- 化学大脑中受影响的大脑区域与小血管疾病,血管痴呆症和阿尔茨海默病 (AD) 中的区域重叠.
- 化疗诱导的神经炎症可能会破坏神经血管单元,导致毒性和大脑形态变化.
- 这些发现突显了化学大脑,神经炎症和神经退行性疾病之间的潜在联系.
相关概念视频
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