与Trigona蜂蜜治疗的糖尿病相关足部的微生物群和愈合状态之间的关系
Sukarni Sukarni1, Mao Kunimitsu2, Kazuhiro Ogai3
1Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, 5-11-80, Kodatsuno, Kanazawa, Ishikawa, 920-0942, Japan; Nursing Department, Faculty of Medicine, Tanjungpura University, Jl. Prof. H. Hadari Nawawi, Pontianak, Kalimantan Barat, 78124, Indonesia.
Journal of tissue viability
|December 24, 2025
概括
微生物群的组成可能会影响糖尿病相关的脚 (DFU) 对蜂蜜治疗的反应. 了解这些细菌差异是改善DFU治疗结果的关键.
科学领域:
- 微生物学 微生物学
- 皮肤病学 皮肤病学
- 糖尿病学 糖尿病学
背景情况:
- 糖尿病相关的足部 (DFU) 是糖尿病的一个重要并发症.
- 蜂蜜具有抗微生物特性,用于治疗DFU,但治疗结果各不相同.
- 微生物群在伤口愈合中的作用及其对蜂蜜治疗疗效的影响尚未完全理解.
研究的目的:
- 调查伤口和周围伤口微生物群之间的关系以及用Trigona蜂蜜治疗的DFU的愈合状态.
- 探索微生物群组成的差异是否解释了DFU中蜂蜜治疗的可变反应.
主要方法:
- 采用一个队列研究设计,对12个DFU进行了研究,分为愈合和恶化组.
- 创伤和周围创伤微生物群在基线和开始蜂蜜应用后一周内被分析.
- 在愈合和恶化组之间比较了微生物群组成.
主要成果:
- 在基线恶化的DFU组中,肠球菌显著高于基线 (p=0.02).
- 在治疗后一周的治愈DFU组中,Corynebacterium显着更高 (p=0.02).
- 根据DFU愈合状态,Prevotella和Brevundimonas在周围伤口皮肤的相对丰度的变化有显著差异.
结论:
- 对蜂蜜的DFU反应可能取决于最初的伤口微生物群组成.
- 伤口和周围环境中的细菌相互作用受到蜂蜜治疗的影响.
- 单独的蜂蜜治疗可能不足以治疗DFU,这表明需要结合策略和进一步研究微生物群动力学.
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