肺功能与发生的认知衰退之间的纵向关联:SONIC队列研究的结果
Yuka Tachibana1, Keigo Kobayashi2, Mai Kabayama2
1Division of Health Sciences, the University of Osaka, Graduate School of Medicine, Suita, Japan; Department of Fundamental Nursing of Shiga University of Medical Science.
肺功能减弱,特别是较低的百分比峰值呼气流 (%PEF) 和1秒内强制呼气量/强制生命能力 (FEV1/FVC) 的比率,与老年人的认知能力下降有关,特别是70多岁的老年人.
科学领域:
- 老年学是一门学科.
- 肺部病理学 肺部病理学
- 神经科学是一个神经科学.
背景情况:
- 肺功能下降是一种常见的衰老过程.
- 认知能力下降是老年人群的一个重大问题.
- 纵向数据将肺功能与认知衰退联系起来,同时考虑混因素,是有限的.
研究的目的:
- 为了研究基线肺功能测量和社区居住的日本老年人的3年认知衰退之间的关联.
- 为了确定螺旋计是否预测认知能力下降,经过对脆弱性,生活方式和并发性疾病进行调整.
主要方法:
- 纵向队列研究 (SONIC研究) 随访3年.
- 参与者年龄在70年代和80年代,按年龄和性别分层.
- 评估肺功能 (例如%PEF,FEV1/FVC),认知 (MoCA-J),虚弱,并发症和健康行为.
主要成果:
- 大多数肺功能指标在3年内下降;FEV1/FVC保持稳定.
- 认知分数 (MoCA-J) 在80年代下降,但在70年代没有下降.
- 降低的%PEF与70多岁的男女的认知能力下降有关.
- 降低FEV1/FVC比率与70多岁女性的认知能力下降有关.
结论:
- 百分比PEF和FEV1/FVC的下降与70多岁的老年人认知能力下降的增加有关.
- 在这些协会中观察到性别差异.
- 简单的肺功能测量可以作为特定老年人群体认知能力下降风险的早期指标.
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