生物标志物 生物标志物
Cally Xiao1, Ganna Blazhenets2, Renaud La Joie2
1Laboratory of Neuro Imaging, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
与非西班牙裔白人相比,西班牙裔参与者脑粉样蛋白水平较低,即使有阿尔茨海默病风险等位基因APOEε4.4. 这一发现表明阿尔茨海默氏症病理进展的种族差异.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 医疗成像医学成像
背景情况:
- 以前的研究表明,阿尔茨海默病 (AD) 风险基因APOEε4与西班牙裔个人相比,与非西班牙裔白人 (NHW) 参与者相比,与较少的轻度认知障碍 (MCI) 病例有关.
- 了解AD病理学的种族差异对于有针对性的干预至关重要.
研究的目的:
- 进行一项元分析,调查APOE基因型与大脑粉样蛋白水平之间的关系中的种族差异.
- 为了确定西班牙裔和NHW参与者是否表现出粉样蛋白负担的差异,用定子发射断层扫描 (PET) 测量粉样蛋白负担,该测量标准化为粉样蛋白尺度.
主要方法:
- 通过使用A4,ADNI,HABS-HD,IDEAS和SCAN等多项大规模研究的数据进行了元分析.
- 综合数据集包括16,831名参与者 (7.8%是西班牙裔),从粉样蛋白PET扫描中计算出粉样蛋白值.
主要成果:
- 西班牙裔参与者比NHW参与者显示出明显较低的平均百叶状体值 (p < 0.001).
- 较小比例的西班牙裔参与者是粉样蛋白阳性 (32%vs52%在NHW) 基于20的粉样蛋白切割值.
- 在患有痴呆症的粉样蛋白阳性个体中,西班牙裔参与者比NHW参与者有较低的粉样蛋白值 (p < 0.001).
结论:
- 认知衰退和APOEε4等位基因都与跨种族更高的百叶状物值相关.
- 西班牙裔参与者始终显示出比NHW参与者更低的Centiloid值,即使有认知诊断和APOEε4等位基因.
- 计划使用额外的数据集进行进一步的研究,以探索人口统计学,基因型,诊断和百叶状物值之间的相互作用.
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516