生物标志物 生物标志物
Shuo Qin1, Eric Kwun Kei Ng1, ChunSiong Soon1
1National University of Singapore, Singapore, Singapore, Singapore.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
老年人睡眠质量差和大脑体积减少相互影响认知功能. 这种双向关系凸显了灰质缩和睡眠碎片化如何对记忆和执行功能产生负面影响.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 睡眠科学 睡眠科学
背景情况:
- 睡眠碎片化和不规则性与老年人的认知能力下降有关.
- 认知能力下降与大脑体积的减少有关,特别是皮质灰质和海马体积的减少.
- 连接睡眠,大脑容量和认知的机制仍然不清楚.
研究的目的:
- 研究睡眠和大脑体积对认知表现的双向调解效应.
- 探索社区居住的老年人睡眠模式,大脑结构和认知功能之间的相互作用.
主要方法:
- 利用Oura环数据评估800名老年人的睡眠模式.
- 进行了全面的神经认知电池以评估认知表现.
- 在467名参与者的MRI数据上使用了部分最小平方相关 (PLSC) 和调解分析,以检查睡眠,大脑体积 (灰质,海马) 和认知之间的关系.
主要成果:
- 具有高规律性和低碎片化的睡眠特征与更好的认知表现相关.
- 大脑体积部分介导了睡眠和认知之间的关系.
- 睡眠部分调解了大脑体积和认知之间的关系,表明双向影响.
结论:
- 在灰质量和睡眠质量之间存在双向的,虽然很小的调解效应.
- 灰质缩和不规则/碎片化睡眠相互作用,对老年人的认知功能产生负面影响.
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