Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Greater choroid plexus volume is linked to poor sleep, neurodegeneration, and cognitive deficits in older adults: Evidence from the IGNITE Study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Inflammatory, metabolic, and vascular pathways linking cardiorespiratory fitness to cognition: Results from the IGNITE study.

Brain, behavior, & immunity - health·2026
Same author

Age-Dependent Remodeling of the Sciatic Nerve Proteome in 5xFAD Mice Can Be Attenuated by Exercise or Donepezil Treatment to Maintain Neuromuscular Function.

Aging cell·2026
Same author

The impact of cognitive behavioral therapy for insomnia on cognitive performance and amyloid beta in older adults: A randomized controlled trial.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Operationalizing AD Biomarker Return of Research Results: Methods from the KU ADRC.

Biopreservation and biobanking·2026
Same author

Physical activity, aerobic fitness, and AD blood biomarkers: The IGNITE study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

相关实验视频

Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

基础科学和病原发生学

Riley E Kemna1,2, Amanda Szabo-Reed1, Paul J Kueck1

  • 1University of Kansas Alzheimer's Disease Research Center, Fairway, KS, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
PubMed
概括
此摘要是机器生成的。

这项研究揭示了老年人中线粒体健康和身体健康的基于性别的差异,影响了炼的好处和阿尔茨海默氏症.

更多相关视频

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

相关实验视频

Last Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

科学领域:

  • 老年学和运动科学
  • 细胞生物学和神经科学
  • 阿尔茨海默氏症疾病研究研究

背景情况:

  • 久坐不动的生活方式增加了阿尔茨海默病 (AD) 的风险,而运动提供神经保护.
  • 女性的性别与较低的身体健康有关,可能会影响AD风险和运动益处.
  • 了解老年人身体健康的细胞机制对于减轻AD风险至关重要.

研究的目的:

  • 探索认知健康的老年人身体健康的基础细胞机制.
  • 研究运动,线粒体健康和阿尔茨海默病 (AD) 风险之间的关系.
  • 检查性行为如何影响身体健康,线粒体健康以及潜在的运动益处.

主要方法:

  • 收集了参与COMET试验的34名认知健康的老年人 (65岁以上) 的血液样本.
  • 通过分级运动测试和使用双能X射线吸收计的身体组成来评估身体健康.
  • 隔离了淋巴细胞,用光标记剂染色它们,并使用流细胞计分析了线粒体健康状况,以获得线粒体健康指数 (MHI).

主要成果:

  • 与女性相比,男性的瘦身量更高,氧气吸收峰值 (VO2峰值) 和线粒体健康指数 (MHI) 更高.
  • 在男性中,MHI随着年龄的增长而下降;在女性中,线粒体反应性氧物种 (ROS) 与瘦体和氧吸收效率斜率 (OUES) 有负相关.
  • 在线粒体健康及其与身体健康参数的关系中观察到基于性别的显著差异.

结论:

  • 线粒体健康和反应性氧物种 (ROS) 的性别特异性差异影响运动反应.
  • 这些发现表明,男性和女性之间对运动训练的可变反应可能会导致阿尔茨海默病 (AD) 风险的性别差异.
  • 这项研究强调了考虑性别作为生物变量在认知健康的运动干预措施中的重要性.