Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Associations of cerebrospinal fluid measures of synaptic function with white matter microstructure and cognition in older adults.

Frontiers in aging neuroscience·2026
Same author

Plasma GDF15 affects long-term dementia risk and alters neuroimmune signaling.

Science advances·2026
Same author

Centrifugal microfluidic automation of the protein aggregation capture workflow for robust mass spectrometry-based proteomics.

Lab on a chip·2026
Same author

Five-year change in brain metabolism across the spectrum of cognitive impairment in older adults: a quantitative MRI study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Disproportionately elevated sulcal index (DESI): An automatically driven index representing disproportionate subarachnoid space enlargement in brain MRI scans.

Brain research bulletin·2026
Same author

Plasma inflammatory markers and brain white matter microstructure in late middle-aged and older adults.

medRxiv : the preprint server for health sciences·2026
Same journal

Patient-derived forebrain cortical organoids reveal biphasic tau-MAP6-microtubule axis dysfunction in tauopathy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Greater choroid plexus volume is linked to poor sleep, neurodegeneration, and cognitive deficits in older adults: Evidence from the IGNITE Study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Plasma-based neurobiological protein biomarkers as predictors of dementia progression: Insights from longitudinal aging study in India - Diagnostic assessment of dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Neuropathology-specific language features in primary progressive aphasia.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Dementia blood biomarkers in the context of post-stroke cognitive outcomes: Systematic review and evidence synthesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
查看所有相关文章

相关实验视频

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

生物标志物 生物标志物

Jan Muntel1,2, Aida Kamalian3, Polina Shichkova1

  • 1Biognosys AG, Schlieren, Zurich, Switzerland.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
PubMed
概括
此摘要是机器生成的。

这项研究确定了用于早期阿尔茨海默病检测的新型血生物标志物,先于认知衰退和粉样蛋白转化. 这些发现为当前的诊断方法提供了一个不那么侵入性的替代方案.

更多相关视频

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

相关实验视频

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

科学领域:

  • 神经科学是一个神经科学.
  • 生物化学 生物化学
  • 生物标志物发现发现

背景情况:

  • 衰老是阿尔茨海默氏症 (AD) 的主要危险因素,但从健康到病态衰老的过渡不清楚.
  • 早期发现AD至关重要,需要在认知症状或粉样蛋白转化之前检测到的生物标志物.
  • 由于其可访问性和非侵入性,等离子体是生物标志物发现的理想矩阵.

研究的目的:

  • 开发一种基于质谱 (MS) 的新型蛋白质组学工作流程,用于在血中发现无偏的生物标志物.
  • 识别与认知衰退和阿尔茨海默病进展相关的早期分子变化.
  • 发现血基生物标志物,这些生物标志物先于粉样蛋白转化和临床症状.

主要方法:

  • 从BIOCARD队列中选择的参与者,根据10年的CSF Aβ42 / Aβ40比率将55个分类为粉样蛋白转化剂和55个匹配的非转化剂.
  • 分析了578个血样本,使用一种基于MS的新型蛋白质组学工作流 (Biognosys P2) 涉及预处理,消化和定量质谱.
  • 收集的纵向数据包括认知评估,临床生物标志物和MRI扫描.

主要成果:

  • 质谱学揭示了与认知衰退和过渡到轻度认知障碍 (MCI) 相关的蛋白质和变化.
  • 确定了关键的生物途径,包括脂质代谢,细胞外矩阵重塑,轴突生成和突触活动.
  • 发现了在粉样蛋白转化和认知衰退之前存在的基于血的特征,在临床转化之前可以检测到.

结论:

  • 一种综合方法将AD的分子变化与临床表型联系起来.
  • 血衍生生物标志物为AD诊断提供了脑脊液 (CSF) 采集的不那么侵入性的替代方案.
  • 这项研究强调了血蛋白质组学在早期AD检测和了解疾病机制方面的潜力.