生物标志物 生物标志物
Anisa Dhana1, Charles Decarli2, Klodian Dhana1
1Rush University Medical Center, Chicago, IL, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
功能受损与较高水平的神经退行生物标志物有关,如神经丝光 (NfL),总 (t-tau) 和状纤维酸性蛋白 (GFAP). 功能没有影响认知衰退率,但影响生物标志物测量.
科学领域:
- 神经学 神经学
- 腎臟病學 (nephrology) 是一種醫學.
- 生物标志物研究 生物标志物研究
背景情况:
- 神经退行生物标志物 (NfL,t-tau,GFAP) 与认知能力下降和阿尔茨海默病风险有关.
- 这些生物标志物的血清水平可能会在功能减弱的个体中升高,不管他们的认知状况如何.
研究的目的:
- 检查功能和血清神经退行生物标志物之间的关联.
- 确定功能障碍是否影响NfL,GFAP和t-tau与纵向认知变化之间的关系.
主要方法:
- 来自芝加哥健康与衰老项目的1207名老年人的分析.
- 通过估计的质过率 (eGFRcr) 评估功能;分类为正常,受损或严重.
- 血清生物标志物用基于珠的免疫试验测量;全球认知通过认知测试评估.
主要成果:
- 较低的eGFRcr与较高的NfL,GFAP和t-tau血清水平相关.
- 与正常功能的人相比,功能受损和严重的个体表现出明显更高的NfL水平.
- 功能没有改变这些生物标志物与认知衰退率之间的关联.
结论:
- 功能受损可以影响神经退行生物标志物的血清水平.
- 在NfL,GFAP和t-tau的研究和临床使用中,应考虑估计的淋巴膜过率 (eGFRcr).
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516