生物标志物 生物标志物
Boxin Sun1,2, Ming Gu1,2, Amanda Cook Maher2,3
1Michigan State University, East Lansing, MI, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
脑电图 (EEG) 的有效连接性和基于血液的pTau-217在检测阿尔茨海默病风险方面表现有前途. 这些生物标志物是相关的,可以结合起来,以改善粉样阳性的早期检测.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物发现发现
- 阿尔茨海默氏症疾病研究研究
背景情况:
- 位子发射断层扫描 (PET) 粉样蛋白成像是早期阿尔茨海默病 (AD) 风险检测的标准.
- 血pTau-217正在成为反映AD病理的基于血液的生物标志物.
- 脑电图 (EEG) 生物标志物显示出预测早期神经退行症的潜力.
研究的目的:
- 为了研究基于EEG的大脑有效连接和血pTau-217水平之间的关系.
- 为了比较EEG有效连接和pTau-217在区分粉素阳性和粉素阴性个体中的表现.
- 评估EEG和pTau-217在预测粉样蛋白状况方面的联合实用性.
主要方法:
- 利用了22名正常认知参与者 (65-88岁) 的数据集,包括7名通过Aβ-PET识别的粉样蛋白阳性和15名粉样蛋白阴性个体.
- 记录了3分钟的闭眼静止状态EEG,并收集了血液用于血pTau-217测量 (SIMOA AlzPath v2测定).
- 应用因果融合交叉映射 (cCCM) 来分析EEG有效连接,并使用机器学习来预测粉样蛋白状况.
主要成果:
- 与粉样蛋白阴性个体相比,粉样蛋白阳性个体的有效连接性发生了变化,观察到连接性减少和增加.
- 某些EEG区域之间的有效连接与血pTau-217水平有很强的相关性 (>0.6).
- 粉样蛋白状况的预测精度为EEG的86.36%,pTau-217的90.91%,两种生物标志物相结合时为95.45%.
结论:
- 基于EEG的有效连接性和血pTau-217是预测粉样蛋白状况的密切相关的生物标志物.
- 这些生物标志物在识别患有AD风险的个体方面显示出互补的潜力.
- 结合EEG和pTau-217生物标志物可以提高早期发现阿尔茨海默病风险.
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516