生物标志物 生物标志物
Yulu Yan1, Huan Ma1, Zihan Wang1
1The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
推迟发作的中风后认知障碍 (PSCI) 影响11.68%的患者. 较高的NIH中风量表 (NHISS) 基线分数和增加的脑血管疾病风险因素与延迟PSCI发展有关.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 脑卒中后认知障碍 (PSCI) 可以表现为早期或延迟.
- 虽然早期PSCI是常见的,但延迟PSCI的发病率和风险因素仍然不太了解.
研究的目的:
- 为了确定延迟发病PSCI的发生率.
- 在急性脑梗塞患者中确定与延迟发作的PSCI相关的风险因素.
主要方法:
- 197名患有急性脑梗塞且没有早期PSCI的患者被随访了24周.
- 使用MoCA评估认知能力;根据既定标准诊断延迟PSCI.
- 后勤回归和相关性分析确定了风险因素.
主要成果:
- 延迟发作的PSCI的发生率为11.68%.
- 在延迟PSCI组中观察到更高的NIH中风量表 (NHISS) 基线得分和更少的定期运动率.
- 多变量分析显示,较高的基线NHISS得分 (OR=1.525) 和更多的脑血管疾病风险因素 (OR=2.904) 与延迟发作的PSCI显著相关.
结论:
- 晚发性PSCI发生在11.68%的急性脑梗塞后患者中.
- 基线NHISS得分升高和多重脑血管疾病风险因素是延迟发病PSCI的显著预测因素.
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