额外的NK/T细胞淋巴瘤的粒状变体:模仿炎症或感染性病变
Mansi Yu1, Xuankai Zeng1, Weixin Luo1
1State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, China; Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, China.
Human pathology
|December 24, 2025
概括
这项研究描述了一种罕见的颗粒状细胞变体,即外节 NK/T 细胞淋巴瘤 (ENKTL). 识别这种形式对于早期诊断和治疗至关重要,因为它经常被误诊为慢性炎症.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 外节NK/T细胞淋巴瘤 (ENKTL) 通常缺乏颗粒瘤的形成.
- 炎症细胞是ENKTL.的常见特征.
研究的目的:
- 描述ENKTL.的罕见粒状变异的临床病理特征.
- 强调识别这种变种的重要性,以避免诊断延迟.
主要方法:
- 追溯分析了四例颗粒状ENKTL的病例.
- 审查四个先前报告的病例.
- 使用了组织病理学,免疫组织化学,爱斯坦-巴尔病毒编码的小RNA (EBER),现场杂交 (ISH) 和下一代测序 (NGS).
主要成果:
- 颗粒状ENKTL变体呈现出广泛的上皮质颗粒瘤,缺乏典型的血管中心性和血管破坏性.
- 在颗粒瘤之间观察到非典型的淋巴细胞.
- 所有病例都与爱斯坦-巴尔病毒 (EBV) 有关.
- 皮肤是最常见的参与部位 (6/8个案例).
- 八个病例中的五个最初被误诊为慢性炎症.
结论:
- 外节NK/T细胞淋巴瘤 (ENKTL) 呈现出多样化的形态特征和生物变异性.
- 提高对粒状变异的认识对于及时诊断和治疗至关重要.
- 及时识别可以防止诊断延迟,并确保适当的治疗干预.
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