儿科心肌病中的左心房功能:一个多中心研究
Jolanda Sabatino1, Martina Avesani2, Sara Moscatelli3
1Department for Women's and Children's Health, University Hospital of Padova, Pediatric and Congenital Cardiology Unit, Via Nicolo` Giustiniani, 2, 35128 Padova, Italy; Pediatric Research Institute (IRP) 'Città della Speranza', Padua, Italy; Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Division of Cardiology, Viale Europa, 1, 88100, Catanzaro, Italy.
概括
左心房储压力 (LAS) 是儿科心肌病患者不良结果的有价值预测指标,为改善风险分层提供了超越传统心声测量措施的见解.
科学领域:
- 心脏病学 心脏病学
- 儿童心脏病学 儿童心脏病学
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
背景情况:
- 左心室缩功能障碍与儿科心肌病的不良结果有关.
- 扩张功能,特别是左心房功能的预后作用,在这个人群中仍未得到充分研究.
研究的目的:
- 评估左心房 (LA) 功能之间的关联,通过2D-speckle跟踪回声心脏成像 (2D-STE) 测量,以及儿科心肌病患者的不良结果.
- 为了确定LA函数是否提供与传统心声回声学参数相比增量预后信息.
主要方法:
- 对138名儿科心肌病患者和45名对照患者的回顾性分析.
- 从基线心声图测量LA储压力 (LAS) 和其他心声学参数 (GLS,LVEF,LAVi,E/e) 的测量.
- 复合终点:心血管死亡,堕胎死亡,VAD植入或心脏移植,使用考克斯模型和ROC曲线进行分析.
主要成果:
- 较低的LAS显著与不良结果相关 (p<0.001).
- 在多变量分析中,LAS独立预测了不良结果,表现优于LA体积指数 (LAVi).
- 对于预测结果,LAS显示曲线下的面积 (AUC) 为0.739.
结论:
- 左心房储压力 (LAS) 独立地与儿科心肌病的不良结果有关.
- LAS提供了超越常规心声回声测量措施的增量预后价值.
- 常规纳入LAS可能会增强风险分层,并指导儿童心肌病的早期干预.
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