相关实验视频

Updated: Jan 7, 2026

$Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain$

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain

Published on: May 10, 2017

在帕金森病患者中,无线传输的亚thalamic核信号解码内源性疼痛水平

Abdi Reza¹, Takufumi Yanagisawa², Naoki Tani³

¹Department of Neurosurgery, Graduate School of Medicine, The University of Osaka, Osaka 565-0871, Japan; Department of Neuroinformatics, Graduate School of Medicine, The University of Osaka, Osaka 565-0871, Japan; Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia.

Neurobiology of disease

|December 24, 2025

概括

研究人员使用亚thalamic核 (STN) 信号来解码帕金森病患者的疼痛水平. STN活动成功地对疼痛强度进行了分类,识别了PD相关疼痛的潜在生物标志物.

科学领域:

神经科学是一个神经科学.
神经学神经学
生物医学工程生物医学工程

背景情况:

疼痛是帕金森病 (PD) 的常见非运动性症状,显著影响患者的生活质量.
了解双边亚thalamic核 (STN) 的作用和确定PD相关疼痛的客观生物标志物仍然具有挑战性.

研究的目的:

研究双边STN信号与帕金森病患者疼痛强度之间的关系.
开发一种机器学习模型,使用STN活动对客观疼痛状态进行分类.
为了确定与PD相关的疼痛相关的潜在STN生物标志物.

主要方法:

记录了帕金森病患者的双边STN信号,这些患者使用了自适应性深度大脑刺激 (DBS) 系统.
收集了患者的疼痛评级和关于疼痛位置和PD关联的注释.
训练了一种机器学习模型,使用STN信号特征来分类较高与较低的疼痛状态.

主要成果:

亚thalamic核 (STN) 活动显著分类疼痛强度在PD相关的疼痛组.
反侧 (和β波段) 和侧 (三角形和波段) 的STN活动对于疼痛分类至关重要.
该研究确定了与PD患者疼痛水平相关的特定STN信号特征.

结论:

双边STN信号可用于客观地解码帕金森病中的疼痛状态.
特定的STN频段 (,β,delta,theta) 显示出潜在的PD相关疼痛生物标志物.
这项研究为了解和潜在地管理帕金森病疼痛提供了一种新的方法.

关键词:

适应性深度大脑刺激内生性疼痛是一种内生性疼痛.机器学习机器学习帕金森病的疾病.

更多相关视频

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Published on: October 20, 2021

相关概念视频

Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

Nociception

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.