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Updated: Jan 7, 2026

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多镇压复合体作为血液恶性瘤治疗点

Makoto Yamagishi1, Atsushi Iwama2, Issay Kitabayashi2

  • 1Laboratory of Viral Oncology and Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Experimental hematology
|December 24, 2025
PubMed
概括

多胞体抑制复合体 (PRC1和PRC2) 调节基因表达,对于造血干细胞维护至关重要. 异常的PRC1/2活性驱动血液恶性瘤,但双EZH1/2抑制剂显示出有前途.

关键词:
多重复合镇压复合体 镇压复合体通过乙化处理.表观遗传调节 表观遗传调节甲基化处理的方法

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