甲基化物的结构多样性决定了对类固醇5α-减少酶1型的共价与非共价抑制机制:特定物种的差异和初步的结构-活性关系

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Junying Chen1, Shufang Qi1, Zijian Lin1

  • 1Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China; Key Laboratory of Pediatric Anesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China; Key Laboratory of Precision Anesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China; Key Laboratory of Environment and Male Reproductive Medicine of Wenzhou, Wenzhou, Zhejiang, 325000, China.

Chemico-biological interactions
|December 24, 2025
PubMed
概括

像o-phthalaldehyde这样的环境化物抑制了类固醇5α-减少酶1型 (SRD5A1),影响了神经类固醇生物合成. 化物结构决定了共价或非共价结合,影响大脑功能,需要对环境健康风险进行评估.

关键词:
5α-还原酶1型的第1种.阿尔德化物是什么协同抑制的协同抑制.非共价抑制 非共价抑制结构与活动的关系.

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