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Updated: Jan 7, 2026

Genome-wide Mapping of Drug-DNA Interactions in Cells with COSMIC Crosslinking of Small Molecules to Isolate Chromatin
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发现了调节AP-1转录因子ΔFOSB的DNA结合和释放的小分子和可用药物的槽

Sean McNeme1, Yun Young Yim2, Ashwani Kumar1

  • 1Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, 77555, USA; Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, Texas, 77555, USA.

The Journal of biological chemistry
|December 24, 2025
PubMed
概括

研究人员在ΔFOSB蛋白上发现了一个新的可服药部位,这是成和慢性疾病的关键因素. 这里结合的小分子可以抑制 ΔFOSBB 的作用.

关键词:
转录因子AP-1 (AP-1) 是一种转录因子.切割和运行 切割和运行DNA与蛋白质的相互作用bZIP 域名 bZIP 域名毒品可供使用的网站基因调节 基因调节 基因调节转录因子的小分子抑制剂.结构生物学结构生物学转录性重编程是一种转录性重编程.的 ΔFOSBB.

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