在ECHO队列中妊娠细颗粒物暴露和围产期结果:跨妊娠窗口的关联

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Updated: May 5, 2026

08:04

Murine Fetal Echocardiography

Published on: February 15, 2013

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Adaeze W Nzegwu¹, Aisha S Dickerson¹, Kristin Miller²

¹Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Environmental research

|December 24, 2025

概括

怀孕早期暴露于细颗粒物 (PM2.5) 与不良的围产期结果有关,特别是女性婴儿的出生体重z分数较低. 在怀孕初期和怀孕前减少PM2.5暴露可能会改善婴儿的健康.

科学领域:

环境健康环境健康
围产期流行病学围产期流行病学
生殖毒理学生殖毒理学

背景情况:

在怀孕期间暴露于细颗粒物 (PM2.5) 的关键窗口上存在不一致的证据,对周围产生的不良结果.
了解PM2.5暴露的时间对于制定有针对性的公共卫生干预措施至关重要.

研究的目的:

研究孕期PM2.5暴露的特定时间与各种围产期结局之间的关联.
识别PM2.5相关的围产期健康不良影响的临界暴露窗口和潜在效果修饰剂.

主要方法:

利用了来自19108个母婴二位数的环境影响儿童健康结果 (ECHO) 队列的数据.
采用高分辨率的空间时空模型,在不同的妊娠窗口 (三个月,第一个三个月的早期/晚期) 中对PM2.5暴露.
应用了线性和Poisson回归的概括估计方程 (GEE) 模型,以评估连续 (妊娠年龄,出生体重z-scores) 和二元 (早产,对于妊娠年龄来说小) 结果的关联.

主要成果:

第一个季度早期的PM2.5暴露 (每增加5μg/m3) 与较低的出生体重z-score (β = -0.03) 和孕期年龄 (SGA) 风险 (RR = 1.06) 的暗示性增加有关.
关联主要观察到女性婴儿,在男性中没有发现显著的联系.
有证据表明,PM2.5与妊娠年龄,早产和SGA术语的相关性可能因母亲的种族和种族而有所不同.

结论:

怀孕早期的PM2.5暴露对围产期健康构成风险,特别影响出生体重z-score.
建议采取旨在减少PM2.5暴露的政策,特别是在怀孕前和怀孕初期,以改善围产期的结果.
需要进一步的研究来阐明妊娠PM2.5暴露的性别特异性和种族/种族特异性影响.

关键词:

出生的体重出生时的体重.环境污染物环境污染物怀孕年龄怀孕年龄婴儿婴儿婴儿婴儿婴儿婴儿颗粒物质颗粒物质是什么怀孕怀孕怀孕怀孕过早出生过早的出生

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