生物标志物 生物标志物
Constance Delaby1,2,3, Aurélie Ladang4, Jose Yriarte5
1Sant Pau Memory Unit, Hospital de la Santa Creu i Sant Pau - Biomedical Research Institute Sant Pau - Universitat Autònoma de Barcelona, Barcelona, Spain.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
在实验室中标准化神经纤维光链 (NfL) 测试对于其用于诊断神经系统疾病至关重要. 这个国际项目开发了一种协调的策略,以改善NfL结果的解释和临床实践中的报告.
科学领域:
- 生物化学 生物化学
- 神经学 神经学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 神经纤维光链 (NfL) 在血液和CSF中的量化有助于神经系统疾病的诊断和预后.
- 临床实践,分析方法和切线的变化阻碍了NfL测试的一致解释.
- 对NfL报告和解释缺乏共识会影响其临床实用性.
研究的目的:
- 解决神经纤维光链 (NfL) 量化和报告在实验室中的变异性.
- 根据使用上下文 (COU) 制定一个协调的使用和报告NfL结果的战略.
主要方法:
- 一个国际项目,涉及18个国家的38个专业实验室.
- 一个问卷收集了关于COU的数据,以及用于NfL定量化的预分析和分析协议.
- 使用共识方法制定了NfL结果报告的协调战略.
主要成果:
- 63%的中心在CSF中量化了NfL,87%在血液中,53%在两者之间.
- 最常见的COU包括前性痴呆症 (71%),阿尔茨海默病 (71%) 和多发性硬化症 (61%).
- 大多数中心使用基于出版的切割值 (50%) 并考虑年龄 (42%);95%报告了数值结果.
结论:
- 协调NfL切断值,报告和解释对于常规临床实践至关重要.
- 标准化的NfL测试将改善神经系统疾病的诊断和预后能力.
相关概念视频
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