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相关概念视频

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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生物标志物 生物标志物

Hanzhang Lu1

  • 1Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
PubMed
概括

核磁共振成像生物标志物对检测血管对认知障碍和痴呆症 (VCID) 的贡献有希望. 脑血流,氧气提取率和脑血管反应率等关键指标为VCID提供了新的诊断工具.

科学领域:

  • 神经成像是一种神经成像.
  • 神经学 神经学
  • 生物标志物发现发现

背景情况:

  • 磁共振成像 (MRI) 对于评估脑血管功能至关重要.
  • 磁力共振成像为开发血管对认知障碍和痴呆症 (VCID) 贡献的生物标志物提供了潜力.

研究的目的:

  • 审查基于MRI的脑血管生理学生物标志物的最新进展.
  • 探索这些生物标志物在诊断和理解VCID中的潜在作用.

主要方法:

  • 讨论三个关键的MRI测量的脑血管参数:脑血流 (CBF),氧气提取分数 (OEF) 和脑血管反应率 (CVR).
  • 大脑血流 (CBF) 是通过非对比性动脉旋转标记 (ASL) MRI 测量.
  • 评估氧气提取分数 (OEF) 和脑血管反应率 (CVR),分别了解氧气供需平衡和血管功能.

主要成果:

  • 在VCID中,CBF在全球范围内减少,与阿尔茨海默氏症痴呆症不同,它与神经活动有关.
  • 在VCID中增加的OEF与血管风险因素相关,并沿纵进展.
  • 降低CVR与认知得分 (MoCA) 和执行功能密切相关,独立于阿尔茨海默病的病理学.

结论:

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  • 基于MRI的脑血管测量显示了作为认知障碍生物标志物的显著潜力.
  • 这些生物标志物对VCID特别有价值,因为诊断选择有限.