生物标志物 生物标志物
M Erin Moir1, Brandon G Fico1,2, Sarean Harmoni A Gaynor-Metzinger1
1University of Wisconsin-Madison, Madison, WI, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
脑脉动率升高与大脑脊髓液中神经退行症标志物有关,这些标志物存在于认知正常的成年人中. 这表明脉动性可能是阿尔茨海默病的早期生物标志物,具有治疗干预的潜力.
科学领域:
- 神经科学是一个神经科学.
- 心血管科学 心血管科学
- 生物标志物发现发现
背景情况:
- 大脑血管调节失调,特别是大脑脉动性升高,是随着年龄的增长而导致阿尔茨海默病 (AD) 的危险因素.
- 连接增加的脉动性与人类大脑健康下降的确切机制尚未完全理解.
- 脉冲性流动可能会损害血脑屏障,影响粉样蛋白β和蛋白水平,神经元损伤和突触功能.
研究的目的:
- 研究大脑脉动率升高与神经退行性脑脊液 (CSF) 生物标志物之间的关联.
- 测试这样的假设,即较高的脑脉动与认知不受损的个体中神经退行症标志物的相关性.
主要方法:
- 207名没有认知障碍的中老年人和老年人接受了腰部穿刺,以分析CSF和3T MRI.
- 在CSF中分析了神经退行性标记物:α-synuclein,Aβ42,NfL,神经原蛋白,pTau和tTau.
- 大脑脉动率指数 (PI) 是从主要内动脉的4D流MRI数据计算出来的.
主要成果:
- 右侧内动脉 (ICA) 和右侧中脑动脉 (MCA) 的高脉动指数 (PI) 与神经丝光 (NfL) 和总 (tTau) 有正相关.
- 左ICA,左脊椎动脉 (VA) 和基底动脉中的PI也显示出与NfL的积极关联.
- 在考虑年龄后,PI和神经退行性标志物之间的关联仍然存在,并观察到一些性别特异性差异.
结论:
- 通过4D流MRI量化的大脑脉动性升高与CSF生物标志物有关,这些生物标志物表明在认知不受损的成年人中神经退行和突触功能障碍.
- 大脑脉动性可能是阿尔茨海默病风险的早期指标.
- 旨在减少大脑脉动性的干预措施可能会减轻神经退行.
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