通过肠道食管给药的药物的稳定性:系统性审查
Lena Alodat1, Wejdan Shahin2, Lina Breik3
1School of Pharmacy and Pharmaceutical Science, Monash University, Melbourne, Victoria, Australia.
通过食管给药药物可能会影响药物的稳定性和生物可用性. 虽然大多数药物保持稳定,但有些药物表现出减少或增强的效果,需要仔细考虑.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
- 药物输送系统 药物输送系统
背景情况:
- 食管对于口服摄入量不足的患者至关重要,用于营养和药物输送.
- 通过食管给药的药物的稳定性需要系统评估.
研究的目的:
- 系统地审查影响药物稳定性的因素,与口服途径相比,当药物通过肠道食管被管理时.
- 专注于在健康人群中将固体剂型转换为液体配方的固体剂型.
主要方法:
- 在PubMed/MEDLINE,Embase和CINAHL的综合文献搜索 (2024年7月至10月).
- 包括研究评估药物在肠道食管中的稳定性;排除没有报告这一结果的研究.
- 使用ROBINS-I,ROB-II,Cochrane工具和QUIN工具进行偏差风险评估.
主要成果:
- 24项研究 (16项体内,4项体外,4项联合) 符合纳入标准.
- 华法林和托尔瓦普坦的稳定性/生物可用性降低 (20.8%的研究).
- 对克洛皮多格雷尔 (8.3%的研究) 观察到增强的吸收;大多数药物保持稳定.
结论:
- 输入肠道食管的使用可能会对药物的稳定性产生不同的影响,这取决于管材料和制剂.
- 尽管大多数药物是稳定的,但仍然存在对不稳定性和质量的担忧.
- 这些发现支持制定基于证据的指导方针,以优化临床实践和患者的治疗结果.
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