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临床表现 临床表现

Darren M Lipnicki1, Ashleigh S Vella1, Erico Costa2

  • 1Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney, Sydney, NSW, Australia.

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概括
此摘要是机器生成的。

在60-69岁的年轻人中,令人不安的梦想预示着痴呆症和阿尔茨海默病 (AD). 这些梦可能是神经退行早期的信号,特别是在男性身上.

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科学领域:

  • 神经科学是一个神经科学.
  • 老年学是一门学科.
  • 睡眠医学 睡眠医学

背景情况:

  • 以前的研究将痛苦的梦想与老年白人美国人的未来痴呆症联系起来.
  • 目前的研究扩展了这一点,通过检查令人不安的梦 (梦,梦) 和它们与阿尔茨海默病 (AD) 和全因痴呆症的关联.
  • 该调查包括了更广泛的年龄范围 (60-89岁) 和多样化的国际人口.

研究的目的:

  • 调查是否令人不安的梦想预测事件所有原因痴呆症和AD.
  • 评估这些预测在不同的年龄组 (60-69岁,70-79岁,80-89岁) 和性别.
  • 探索令人不安的梦想作为痴呆症和AD的临床前指标的潜力.

主要方法:

  • 利用了来自巴西,中国,法国,意大利,韩国和台湾的六项纵向队列研究的数据,涉及8339名没有基线痴呆或帕金森病的参与者.
  • 协调了令人不安的梦想数据 (是/否,每周的频率) 并使用了可克斯回归与随机效应进行研究,按性别和年龄分层.
  • 调整了21个共变量,包括睡眠问题,药物,抑郁症和APOE*4,以及包括焦虑在内的额外分析.

主要成果:

  • 总的来说,令人不安的梦想并没有预测所有年龄组或性别的痴呆症或AD.
  • 然而,令人不安的梦想预测了男性的AD (OR=2.03-4.00) 和痴呆症 (OR=1.89-3.93) 以及60-69岁的个体的AD (OR=4.96).
  • 每周令人不安的梦 (<1/周或≥1/周) 在多个分析中显著预测了痴呆症和阿尔茨海默病,特别是在60-69岁年龄组.

结论:

  • 在60-69岁的个人中,令人不安的梦想是发生痴呆症和AD的重要预测因素.
  • 在60-89岁的男性中,令人不安的梦也预测了发生的AD事件.
  • 这些发现表明,令人不安的梦可能是痴呆症和阿尔茨海默病的早期临床前指标或前兆.