Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Midlife Measures of General Cognitive Performance in the National Longitudinal Study of Adolescent to Adult Health (Add Health).

medRxiv : the preprint server for health sciences·2026
Same author

The Epilepsy-Cog study: Methods to establish a harmonized study of late onset epilepsy in a metacohort of six population-based cohorts in the United States.

Epilepsia·2026
Same author

Associations of cerebrospinal fluid measures of synaptic function with white matter microstructure and cognition in older adults.

Frontiers in aging neuroscience·2026
Same author

Risk and protective factors for cognitive decline in older adults from a nationally representative sample in India: Results from the LASI-DAD.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Plasma GDF15 affects long-term dementia risk and alters neuroimmune signaling.

Science advances·2026
Same author

Physical frailty, depression and multimorbidity among older adults in Lima, Peru: a cross-sectional study.

BMC geriatrics·2026

相关实验视频

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

生物标志物 生物标志物

Claire L Anderson1, Alden L Gross2,3, Corinne Pettigrew1

  • 1Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
PubMed
概括
此摘要是机器生成的。

高水平的突触蛋白质神经素2 (NPTX2) 和VGF可能会防止认知能力下降,即使是阿尔茨海默氏症 (AD) 病理. 这些发现表明AD和相关的神经退行性疾病的潜在治疗点.

更多相关视频

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

相关实验视频

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

科学领域:

  • 神经科学是一个神经科学.
  • 生物标志物 生物标志物
  • 神经退行性疾病 神经退行性疾病

背景情况:

  • 像神经素2 (NPTX2) 和VGF这样的突触蛋白可能会提供抗阿尔茨海默病 (AD) 和其他神经退行性疾病的抵抗力.
  • 在临床前AD期间了解这些突触蛋白对于早期干预至关重要.

研究的目的:

  • 研究基线脑脊液 (CSF) 中VGF,NPTX2和GluA4水平与认知不受损个体的长期认知轨迹之间的关联.
  • 为了确定这些突触蛋白是否能够独立于AD病理生物标志物预测认知衰退.

主要方法:

  • 在269名认知不受损的参与者中,使用质谱测量测量了NPTX2,GluA4和VGF的CSF水平.
  • 阿尔茨海默病的生物标志物 (Ab1-42/Ab1-40,p-tau181) 通过使用Lumipulse G1200试验量化.
  • 线性混合效应模型分析了突触蛋白和认知表现之间的关联,平均随访时间为15.9年.

主要成果:

  • 较高的NPTX2和VGF基线水平与全球认知和情节性记忆下降的速度较慢有关,即使考虑到AD生物标志物水平.
  • VGF也与执行功能下降的减少有关,在NPTX2.2.中观察到类似的趋势.
  • 在GluA4水平和认知变化之间没有发现显著的关联.

结论:

  • 基线NPTX2和VGF水平与保持认知功能有关,这表明在AD病理存在时,对认知衰退的保护作用.
  • 这些突触蛋白可能代表减轻AD认知衰退的潜在治疗点.
  • 这些发现支持了神经退行性疾病中突触弹性机制的假设.