生物标志物 生物标志物
Robert W Deering1, Neal S Parikh1, Sasikiran Goteti1
1Alnylam Pharmaceuticals, Inc., Cambridge, MA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
大约26%的认知问题参与者可能患有大脑粉样血管病变 (CAA). 高龄,痴呆症严重程度和APOE4基因型与更高的CAA概率有关.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 老年医学 老年医学
背景情况:
- 大脑粉样蛋白血管病变 (CAA) 涉及大脑血管中的粉样蛋白β沉积,导致认知能力下降和潜在的出血.
- 确定CAA至关重要,因为它会影响某些疗法的治疗决策.
- 这项研究旨在确定阿尔茨海默病神经成像计划 (ADNI) 队列中可能的CAA的流行率.
研究的目的:
- 用波士顿标准版本2.0.0.来估计ADNI参与者可能患有大脑粉样血管病变 (CAA) 的比例.
- 在这个队列中确定与可能的CAA相关的基线特征.
主要方法:
- 利用了认知症状 (CDR-SB > 0) 的ADNI参与者的MRI数据 (3D T1,FLAIR,T2* GRE).
- 盲人神经放射学家应用波士顿标准v2.0来分类CAA的严重程度 (没有,可能,可能).
- 回归分析确定了与可能的CAA相关的因素;评估了读者之间的变化.
主要成果:
- 在828名参与者中,25.7%的人可能患有CAA.
- 在可能的CAA组中,46.9%患有轻度认知障碍,44.6%患有痴呆症.
- 年龄较大,CDR-SB得分较高和APOE4同性与可能的CAA有显著关联.
结论:
- 在约26%的ADNI参与者中发现了可能的CAA,他们有认知症状.
- 年龄,痴呆症严重程度和APOE4基因型可以预测CAA的可能性.
- 强调在患有认知症状的患者中评估CAA的重要性,以及需要量身定制的研究和临床方法.
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