临床表现 临床表现
1Singapore General Hospital, Singapore, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore; Duke-NUS Medical School, Singapore, Singapore.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
主观认知衰退 (SCD) 在患有神经认知障碍 (NCD) 的人与没有患有神经认知障碍的人有不同的模式. 了解这些独特的SCD轨迹可以帮助早期NCD风险评估和干预.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 认知心理学 认知心理学
背景情况:
- 主观认知衰退 (SCD) 预测神经认知障碍 (NCD),但其性质仍有争议.
- 许多患有SCD的人不会发展为NCD,这导致了功能性认知障碍的概念.
- 这项研究将SCD轨迹区分为那些患有和没有发展NCD的人.
研究的目的:
- 检查主观认知衰退 (SCD) 轨迹中的明显差异.
- 为了比较SCD发展神经认知障碍 (NCD) 的个体与保持认知正常的个体的SCD进展.
- 为早期NCD风险识别和公共卫生战略提供信息.
主要方法:
- 一项针对5167名年龄≥50岁的参与者进行的病例控制研究,随访时间中位数为8.1年.
- 病例发生了NCD事件;对照组在≥10年的随访期间具有正常的认知能力.
- 混合效应物流回归模拟了SCD轨迹,使用向后时间表.
主要成果:
- 患有非传染性疾病的个体在20年内出现了新发性SCD,在诊断前13-14年内变得突出.
- 没有发展NCD的个人从年轻时就报告了SCD,随着时间的推移,其概率是恒定的.
- 这些独特的SCD轨迹在阿尔茨海默氏症和非阿尔茨海默氏症疾病以及精神疾病患者中一致.
结论:
- 主观认知衰退 (SCD) 呈现出明显的轨迹,区分到神经认知障碍 (NCD) 的进展.
- 这些轨迹可以提高早期的NCD风险评估,并指导公共卫生信息传递.
- 未来的SCD评估可能需要20年的视角来有效地捕捉新出现的症状.
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