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临床表现 临床表现

Ifrah Zawar1, Jaideep Kapur1, Meghan K Mattos1

  • 1University of Virginia, Charlottesville, VA, USA.

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概括
此摘要是机器生成的。

活跃严重损害了老年人的日常生活工具活动 (IADL),无论他们的认知状态如何. 在那些有活跃发作的人群中,这种下降速度更快,突出了IADL评估和发作管理的需要.

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科学领域:

  • 老年学是一门学科.
  • 神经学 神经学
  • 公共卫生 公共卫生

背景情况:

  • 在患有发作 (PWS) 的老年人中,认知缺陷很普遍,通常会影响日常生活的仪器活动 (IADL).
  • 活跃与远程发作对IADL损伤和老年PWS下降的具体影响仍未得到充分探索.
  • 这项研究研究了老年人发作状态和IADL功能之间的关系,考虑到认知状态.

研究的目的:

  • 检查活跃和远程发作与老年人基线IADL损伤之间的关联.
  • 根据状态,调查老年人具有或没有认知障碍的IADL的纵向下降情况.
  • 为了确定活动性是否与认知能力相比,不成比例地影响IADL表现.

主要方法:

  • 这是一项前性研究,涉及42个美国阿尔茨海默氏病研究中心的20486名认知正常和30238名认知受损的参与者.
  • 参与者被分为活跃发作,远程发作和没有发作 (对照组).
  • 每日生活中的仪器活动 (IADL) 用Pfeffer功能活动问卷 (FAQ) 进行了评估,并进行了统计分析,包括ANOVA和多变量线性回归.

主要成果:

  • 与远程发作或对照相比,主动发作与认知正常和认知受损的老年人初始IADL表现显著差.
  • 与对照组相比,在认知上正常,但发作活跃的个体表现出IADL的纵向下降速度更快.
  • 积极发作参与者的IADL损伤不成比例地高于他们的认知状态,特别是在管理财务和日常任务方面.

结论:

  • 活跃性发作与老年人IADL表现较差和IADL衰退加速有关,无论认知状态如何.
  • 这些发现强调了在老年PWS中进行常规IADL评估的重要性,以确定对援助的需求.
  • 建议采取积极的发作管理,以帮助活跃发作的老年人保持独立性.