Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Optimizing functional connectivity scanning conditions for predicting autistic traits.

Nature. Mental health·2026
Same author

Sleep duration and amyloid status moderate the association between mood symptoms and amygdalar tau in preclinical Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Feature selection leads to divergent neurobiological interpretations of brain-based machine learning biomarkers.

Nature human behaviour·2026
Same author

Feature overlap in transdiagnostic connectome-based models of sustained attention and autism symptoms.

medRxiv : the preprint server for health sciences·2026
Same author

Harmonizing brain rhythms: cortex-wide neuronal dynamics underpin quasi-periodic patterns in resting-state fMRI.

bioRxiv : the preprint server for biology·2026
Same author

Gonadotropins Across the Lifespan: Their role in the Neurodevelopment-Neurodegeneration Continuum.

The Yale journal of biology and medicine·2026
Same journal

Association of sleep duration with Alzheimer's disease and cognition.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Patient-derived forebrain cortical organoids reveal biphasic tau-MAP6-microtubule axis dysfunction in tauopathy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Greater choroid plexus volume is linked to poor sleep, neurodegeneration, and cognitive deficits in older adults: Evidence from the IGNITE Study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Plasma-based neurobiological protein biomarkers as predictors of dementia progression: Insights from longitudinal aging study in India - Diagnostic assessment of dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Neuropathology-specific language features in primary progressive aphasia.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
查看所有相关文章

相关实验视频

Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K

临床表现 临床表现

Hae Young H Yi1, Bronte Ficek-Tani1,2, Corey Horien1,3

  • 1Yale School of Medicine, New Haven, CT, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
PubMed
概括
此摘要是机器生成的。

在阿尔茨海默病 (AD) 中的眼动模式可能为认知功能提供了洞察力. 非amnestic的AD患者表现出与视觉空间技能相关的不同固定时间,这取决于图像类型,这表明在临床评估中可能会使用眼睛跟踪.

更多相关视频

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K

相关实验视频

Last Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K

科学领域:

  • 神经科学是一个神经科学.
  • 眼科医生 眼科 眼科
  • 认知科学 认知科学

背景情况:

  • 眼动异常是阿尔茨海默病 (AD) 的早期指标.
  • 与对照组相比,视觉搜索任务揭示了阿兹海默症患者的反应时间较慢和固定模式的改变.
  • 眼睛跟踪范式为评估认知障碍提供了有价值的工具,特别是在无法完成传统神经心理测试的患者中.

研究的目的:

  • 研究阿尔茨海默病中眼动指标和视觉空间功能之间的关系.
  • 要确定刺激类别 (情感面孔与中性场景) 是否影响这些关系.
  • 探索眼睛跟踪对评估AD认知障碍的有用性.

主要方法:

  • 在中性场景和情感面孔的自由观看期间收集的扫描器内眼睛跟踪数据 (停留时间,固定时间,跳动幅度).
  • 在扫描仪之外进行的神经心理测试,评估视觉空间功能和一般认知 (例如,WAIS-III块设计,JLO,HVOT,MMSE).
  • 使用ANOVA和线性回归来比较健康对照组 (HC),记忆障碍患者和非记忆障碍患者之间的眼睛跟踪和认知表现.

主要成果:

  • 非amnestic AD参与者比amnestic AD和HC组显著表现出较差的视觉空间功能.
  • 在眼睛跟踪指标或与认知表现的一般关系中没有观察到整体群体差异.
  • 在非amnestic AD中,固定持续时间与面部与场景的视觉空间分数有不同的相关性 (面部试验中对JLO/Block Design负,场景试验中呈阳性).

结论:

  • 没有记忆障碍的AD参与者在基于刺激类型 (面孔与场景) 的固定时间和视觉空间表现之间显示出明显的关联.
  • 增强的情感面部采样可能有利于非记忆障碍AD的视觉空间任务执行.
  • 眼动指标可以为解释AD神经心理测试结果提供有价值的补充信息,强调其临床相关性.