[关于产前暴露与学龄前儿童内化和外化问题的关系研究]
1Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University/Key Laboratory of Population Health Across Life Cycle, Ministry of Education/Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Course, Hefei 230032, China.
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
|December 24, 2025
概括
产前暴露与儿童内化问题增加有关. 新生儿的高含量也与外部化问题相关,特别是在男孩身上.
科学领域:
- 环境健康 环境健康
- 儿科心理学 儿科心理学
- 毒理学 毒理学 毒理学
背景情况:
- 产前暴露于环境因素可能会影响儿童的神经发育.
- (Mo) 是一种必不可少的微量元素,但它在产前发育和儿童行为中的作用需要进一步调查.
- 了解母亲和新生儿水平与儿童行为结果之间的关联对于公共卫生至关重要.
研究的目的:
- 调查产前暴露与学龄前儿童内化/外化问题之间的关联.
- 探索这些关联中的潜在的性别特异差异.
- 为了确定含量在不同怀孕季度和新生儿带血中的影响.
主要方法:
- 一项队列研究包括2514对母婴.
- 使用ICP-MS测量了母亲血清和新生儿带血中的合物度.
- 儿童行为在4岁时使用儿童行为检查表 (CBCL) 进行评估.
- 后勤回归模型分析了含量 (低,中,高) 和行为问题之间的关联,并对混因素进行了调整.
主要成果:
- 中度产前暴露与内化问题的风险增加有关 (OR=1.32).
- 新生儿带血中高的基含量与外部化问题的风险增加有关 (OR=1.72).
- 性别分层分析显示,在男孩中,产前暴露与内化问题之间存在显著的关联,但在女孩中没有.
结论:
- 产前暴露与儿童内化问题的风险增加有关.
- 新生儿高含量与外部化问题的风险增加有关.
- 男孩似乎更容易受到产前暴露对内化行为的影响.
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