临床表现 临床表现
James E Galvin1, Katherine C Almonte1, Andrea D Buehler1
1University of Miami Miller School of Medicine, Boca Raton, FL, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
健康大脑9 (HB9) 工具有效地识别了不同类型的老年人的主观认知衰退 (SCD). 这种自我报告评估有助于早期检测潜在的神经退行性疾病,以便及时干预.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 认知科学 认知科学
背景情况:
- 主观认知衰退 (SCD) 影响了超过45岁的成年人中的10%,跨种族群体的患病率各不相同.
- SCD是轻度认知障碍 (MCI) 和痴呆症的潜在风险因素.
- 健康大脑9 (HB9) 是作为一种自我报告工具来评估认知功能及其对日常生活的影响.
研究的目的:
- 在多元化,基于社区的队列中验证HB9评估工具.
- 评估HB9与已建立的临床,认知和生物标志物措施的相关性.
- 为了确定HB9在识别SCD个体中的有效性.
主要方法:
- 来自健康大脑倡议的357名参与者接受了全面的评估,包括HB9.
- 根据临床评估,神经心理测试,MRI和血液生物标志物,HB9得到了验证.
- 统计分析检查了HB9分数与各种健康和认知指标之间的相关性.
主要成果:
- HB9与主观认知功能指标 (AD8,QDRS) 有中度的相关性,与客观认知测试和生物标志物有较弱的相关性.
- 该工具在不同的种族,社会和人口统计学和诊断群体中始终保持一致.
- 在HB9的切线分数为3.5,有效地歧视了SCD,AUC为0.845.5.
结论:
- HB9作为评估SCD的宝贵工具,特别是在识别可能处于神经退行性疾病早期阶段的个体.
- 虽然不是诊断工具,但HB9可以帮助监测和促进临床试验的招生.
- HB9分数与性,身体表现,情绪,压力和整体功能相关.
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