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临床表现 临床表现

James E Galvin1, Katherine C Almonte1, Andrea D Buehler1

  • 1University of Miami Miller School of Medicine, Boca Raton, FL, USA.

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PubMed
概括
此摘要是机器生成的。

健康大脑9 (HB9) 工具有效地识别了不同类型的老年人的主观认知衰退 (SCD). 这种自我报告评估有助于早期检测潜在的神经退行性疾病,以便及时干预.

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科学领域:

  • 神经学 神经学
  • 老年学是一门学科.
  • 认知科学 认知科学

背景情况:

  • 主观认知衰退 (SCD) 影响了超过45岁的成年人中的10%,跨种族群体的患病率各不相同.
  • SCD是轻度认知障碍 (MCI) 和痴呆症的潜在风险因素.
  • 健康大脑9 (HB9) 是作为一种自我报告工具来评估认知功能及其对日常生活的影响.

研究的目的:

  • 在多元化,基于社区的队列中验证HB9评估工具.
  • 评估HB9与已建立的临床,认知和生物标志物措施的相关性.
  • 为了确定HB9在识别SCD个体中的有效性.

主要方法:

  • 来自健康大脑倡议的357名参与者接受了全面的评估,包括HB9.
  • 根据临床评估,神经心理测试,MRI和血液生物标志物,HB9得到了验证.
  • 统计分析检查了HB9分数与各种健康和认知指标之间的相关性.

主要成果:

  • HB9与主观认知功能指标 (AD8,QDRS) 有中度的相关性,与客观认知测试和生物标志物有较弱的相关性.
  • 该工具在不同的种族,社会和人口统计学和诊断群体中始终保持一致.
  • 在HB9的切线分数为3.5,有效地歧视了SCD,AUC为0.845.5.

结论:

  • HB9作为评估SCD的宝贵工具,特别是在识别可能处于神经退行性疾病早期阶段的个体.
  • 虽然不是诊断工具,但HB9可以帮助监测和促进临床试验的招生.
  • HB9分数与性,身体表现,情绪,压力和整体功能相关.