临床表现 临床表现
Guilherme Briczinski Souza1, Daniel Coswig Zitzke1, Gabriela Sanches1
1Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
这项研究发现,阿尔茨海默病患者的阅读能力较低与发言基本频率较高有关. 数字语音标记可能为阿尔茨海默病 (AD) 阅读困难提供新的见解.
科学领域:
- 神经学 神经学
- 语音语言病理学 语言病理学
背景情况:
- 阿尔茨海默病 (AD) 显著影响认知功能,包括阅读和写作.
- 准确和有效的评估工具对于诊断AD相关的沟通缺陷和规划康复至关重要.
- 数字语音标记器对评估语音和语音任务,如阅读,显示出有希望.
研究的目的:
- 研究在阅读任务中数字语音标记与AD的巴西葡萄牙语说者自我报告的阅读结果之间的关系.
- 探索语音分析对评估阿尔茨海默病患者阅读能力的有用性.
主要方法:
- 被诊断患有阿尔茨海默氏症 (AD) 的识字个体参与了这项研究.
- 参与者填写了一份关于口语能力和阅读困难的自我报告问卷.
- 使用阅读段落的任务收集了语音样本,这些样本是通过工具包来检查仿真语言 (TELL) 应用程序收集的.
- 分析了语音定时,音调相关和语音质量的特征.
- 斯皮尔曼的相关性被用来测试语音标记和自我报告得分之间的关联 (p < 0.05).
主要成果:
- 这项研究包括15名患有AD的个人.
- 在自我报告的阅读能力和基本频率 (r = -0.581,p = 0.023) 之间观察到显著的负相关性.
- 较低的自我报告阅读能力与更高的基本频率有关.
结论:
- 阅读能力的自我感知与语音运动控制,特别是语音特征之间存在潜在的联系.
- 这些初步发现表明,像基本频率一样,数字语音标记在评估阿尔茨海默病中阅读困难时可能是有价值的.
- 需要使用更大的样本大小和先进分析进行进一步的研究,以确认这些结果并探索混因素.
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