临床表现 临床表现
Floor Duits1,2, Paula I Vanneste2,3, Niki S M Schoonenboom4
1Alzheimer Center Amsterdam, Department of Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, Netherlands.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
基于血液的生物标志物 (BBM) 显示出改善阿尔茨海默病 (AD) 诊断的希望. 这些研究将评估BBM在荷兰记忆诊所的临床影响和实用性,旨在提高诊断准确性和速度.
科学领域:
- 神经学 神经学
- 生物标志物研究 生物标志物研究
- 临床诊断 临床诊断 临床诊断
背景情况:
- 在临床实践中,阿尔茨海默氏病 (AD) 诊断往往是延迟的和不准确的.
- 基于血液的生物标志物 (BBM) 为准确的AD检测提供了一个有希望的途径.
- 需要关于BBMs临床影响的现实世界的证据.
研究的目的:
- 在记忆诊所中研究BBMs对AD的临床影响和诊断实用性.
- 收集关于在临床实践中实施BBM的现实世界的证据.
- 在荷兰的记忆诊所中制定BBM的适当使用标准.
主要方法:
- 设计了两项研究:一种诊断性随机对照试验 (n=550) 和一种实用性研究 (n>450).
- 诊断试验将评估披露p-tau217和血清NfL结果对患者管理,诊断和诊断时间的影响.
- 实用性研究将评估BBM对临床医生的日常实践决策的影响.
主要成果:
- 待IRB批准;预计招聘将于2025年第一季度开始.
- 目前,CSF或PET生物标志物在记忆诊所 (0-25%的病例) 中没有常规使用.
- 假设:BBM将提高诊断的准确性,信心,并缩短诊断的时间.
结论:
- AD BBMs正在迅速向临床实践迈进,有可能产生重大影响.
- 记忆诊所的医生认识到BBMs的优势.
- 这些研究将促进熟悉和开发的BBM使用标准在荷兰的记忆诊所.
相关概念视频
Chronic Kidney Disease II: Clinical Manifestations
520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
Coronary Artery Disease III: Clinical Manifestations
299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
Endocarditis II: Clinical Features of Infective Endocarditis
364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
Heart Failure III: Clinical Manifestations
436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
Gastroesophageal Reflux Disease II: Clinical Features and Management
652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
Hypertension III: Clinical Manifestations and Diagnostic Studies
437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437


