光立体学相关的和多基物质 (PFAS) 的发育毒性显示出对研究较少的功能组的担忧
Yuexin Cao1, Hajar Smaili1, Hazel Q Shanks2
1Department of Civil & Environmental Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.
Environmental science & technology
|December 24, 2025
概括
在半导体光刻法中使用的某些和多基物质 (PFAS) 会导致斑马鱼的发育毒性. 一些PFAS显著降低与脂质代谢相关的基因的调节,即使在低度下,也引发了安全问题.
科学领域:
- 环境毒理学环境毒理学
- 化学安全 化学安全
- 半导体制造业 半导体制造业
背景情况:
- 在半导体制造中广泛使用的Per-和多基物质 (PFAS).
- 在光刻法中使用的许多PFAS缺乏毒理学特征.
- 了解PFAS毒性对于开发更安全的替代品至关重要.
研究的目的:
- 通过斑马鱼胚胎测定,评估九种光刻法相关的PFAS的发育毒性.
- 研究与生长和脂质代谢相关的基因表达变化.
- 为半导体制造业中PFAS诱导的毒性提供机械洞察力.
主要方法:
- 斑马鱼胚胎测定用于发展性毒性评估.
- 对特定基因的基因表达分析 (fgf10a, igf1, fabp10a, pparg, mttp).
- 对9种传统和新兴的PFAS进行曝光评估,这些 PFAS与光刻法相关.
主要成果:
- 暴露于PFAS导致死亡率增加和形,如游泳膀膨胀失败和黄囊胀.
- 某些PFAS显著降低了pparg和mttp基因表达的调节,影响了脂质代谢.
- 关键基因的下调甚至发生在环境相关的PFAS度.
结论:
- 具有较少研究的功能组的新兴PFAS可能比传统PFAS更有毒.
- 在光刻法中使用的PFAS可以诱导发育性毒性并改变脂质代谢途径.
- 这些发现支持在半导体制造中选择更安全的化学品,以减轻PFAS风险.
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