生物标志物 生物标志物
Biqi Wang1, Huitong Ding2,3, Derek Qi4
1University of Massachusetts Medical School, Worcester, MA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
加快的大脑衰老与认知功能下降以及阿尔茨海默病和中风风险增加有关. 血生物标志物可能有助于监测大脑健康并识别有风险的个体.
科学领域:
- 神经科学是一个神经科学.
- 基因组学就是基因组学.
- 生物标志物发现发现
背景情况:
- 大脑衰老对于理解认知衰退和神经退行性疾病至关重要.
- 早期发现大脑衰老标志物,可以及时对与年龄相关的神经疾病进行干预.
研究的目的:
- 研究大脑衰老,认知功能和神经退行性疾病风险之间的关联.
- 确定潜在的基于等离子体的生物标志物来监测认知健康.
主要方法:
- 利用了英国生物库蛋白质组学数据 (Olink) 和弗雷明汉心脏研究 (FHS) 数据 (SOMAscan).
- 使用LASSO回归计算的大脑年龄,非器官特定年龄和蛋白质年龄.
- 通过线性回归评估与认知功能的关联,并通过考克斯模型评估疾病风险.
主要成果:
- 加快的大脑衰老与时间学年龄 (r=0.72) 和53005名英国生物库参与者的较低认知分数相关.
- 加快的大脑衰老增加了阿尔茨海默病 (HR=1.88) 和中风 (HR=1.30) 的风险.
- 在FHS中复制显示与注意力降低 (P=0.03) 和中风风险增加 (HR=1.19) 有关.
结论:
- 大脑衰老与两个队列的认知表现和与大脑相关的疾病风险有关.
- 血生物标志物显示出监测认知健康和识别患有神经疾病风险的个体的潜力.
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516