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破坏DNA的毒剂通过Src-STAT1-IRF1路径诱导PD-L1的表达.

Yuri Suzuki1, Soshi Nishibu1, Akihiro Nohara1

  • 1Department of Cancer Cell Biology, Faculty of Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

Biological & pharmaceutical bulletin
|December 24, 2025
PubMed
概括

化学疗法药物,如SN-38和西斯普拉丁,通过一个独立于JAK的途径,通过编程的细胞死亡配体1 (PD-L1) 表达. 这一发现可能会提高免疫检查点抑制剂 (ICI) 在各种癌症中的有效性.

关键词:
造成的DNA损伤是DNA损伤.亚努斯酶是亚努斯酶的一种.免疫疗法 免疫疗法干扰素调节因子1 (IRF1)编程细胞死亡连接物1 (PD-L1)

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